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T2877

Sigma-Aldrich

3,3′,5-三碘代-L-甲状腺原氨酸

≥95% (HPLC), powder

别名:

O-(4-羟基-3-碘苯基)-3,5-二碘代-L-酪氨酸, T3, 碘噻罗宁

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About This Item

经验公式（希尔记法）:
C15H12I3NO4
CAS号:
6893-02-3
分子量:
650.97
Beilstein:
2710227
EC號碼:
229-999-3
MDL號碼:
MFCD00002593
分類程式碼代碼:
51111800
PubChem物質ID:
24900088
NACRES:
NA.32

生物源

synthetic (organic)

品質等級

200

無菌

non-sterile

化驗

≥95% (HPLC)

形狀

powder

光學活性

[α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2

技術

transfection: suitable

mp

234-238 °C (lit.)

溶解度

4 M NH4OH in methanol: 5 mg/mL, clear to very slightly hazy, colorless to light yellow

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

InChI 密鑰

AUYYCJSJGJYCDS-LBPRGKRZSA-N

基因資訊

human ... THRA(7067) , THRB(7068)
rat ... Thra(81812) , Thrb(24831)

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相关类别

應用

3,3′5-三碘-L-甲状腺原氨酸可用于胰岛素样生长因子I的检测，采用双抗体放射免疫分析法。该产品还可用于293T细胞的 体外 转染。

生化／生理作用

3,3′5-三碘-L-甲状腺原氨酸也称为O-(4-羟基-3-碘苯)-3,5-二碘-L-酪氨酸或T3，是具有生物活性的甲状腺激素。在甲状腺功能减退症中，三碘腺苷能增强情绪和神经心理功能。本品对肝脏FGF21表达也有正向调节作用并通过提高许多代谢酶（如用于氧化磷酸化的己糖激酶、肝脏葡萄糖6-磷酸酶以及线粒体酶）的水平，促进葡萄糖、脂肪和蛋白质的代谢分解。此外，该产品可促进儿童正常身体生长，并对胎儿中枢神经系统的成熟至关重要。

準備報告

3,3′5-三碘-L-甲状腺原氨酸以5 mg/ml溶于4M NH4OH的MeOH中，生成无色至淡黄色，澄清至略模糊的溶液。

其他說明

本品未经过细胞培养测试。我们另外提供适合细胞培养的无菌版产品：经过细胞培养检测的T5516无菌制剂。详见产品页面——T2877

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H372

危險分類

STOT RE 1

標靶器官

Thyroid,Cardio-vascular system,Kidney

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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W A Head et al.
Journal of animal science, 74(9), 2152-2157 (1996-09-01)
Targhee ewes (n = 22, average age 5 yr) rearing twin lambs were used to investigate serum growth hormone (GH), IGF-I, triiodothyronine (T3), thyroxine (T4), and prolactin (PRL; ewes only) concentrations associated with selection pressure for lifetime production of kilograms
R Bunevicius et al.
The New England journal of medicine, 340(6), 424-429 (1999-02-11)
Patients with hypothyroidism are usually treated with thyroxine (levothyroxine) only, although both thyroxine and triiodothyronine are secreted by the normal thyroid gland. Whether thyroid secretion of triiodothyronine is physiologically important is unknown. We compared the effects of thyroxine alone with
Soledad Bárez-López et al.
PloS one, 14(12), e0226017-e0226017 (2019-12-07)
Patients lacking the thyroid hormone (TH) transporter MCT8 present abnormal serum levels of TH: low thyroxine and high triiodothyronine. They also have severe neurodevelopmental defects resulting from cerebral hypothyroidism, most likely due to impaired TH transport across the brain barriers.
Andrew C Adams et al.
The Journal of biological chemistry, 285(19), 14078-14082 (2010-03-20)
Thyroid hormone has profound and diverse effects on liver metabolism. Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifically induces hepatic expression of the metabolic regulator fibroblast growth factor 21 (FGF21). Mice treated with T3 showed a
Takahiro Nojiri et al.
Endocrine journal, 66(5), 409-422 (2019-03-01)
Graves' Disease is a representative autoimmune thyroid disease that presents with hyperthyroidism. Emerging evidence has shown the involvement of lysophosphatidic acid (LPA) and its producing enzyme, autotaxin (ATX), in the pathogenesis of various diseases; among them, the involvement of the
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