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Key Documents

T0251

Sigma-Aldrich

胸腺嘧啶核苷5′-三磷酸 钠盐

≥96%

别名:

TTP, dTTP

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About This Item

经验公式（希尔记法）:
C10H16N2O14P3Na
CAS号:
18423-43-3
分子量:
504.15
MDL號碼:
MFCD00080338
分類程式碼代碼:
41106305
PubChem物質ID:
24899873
NACRES:
NA.51

化驗

≥96%

運輸包裝

dry ice

儲存溫度

−20°C

InChI

1S/C10H17N2O14P3.Na.H/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18;;/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18);;

InChI 密鑰

KAELIXTVSANDSE-UHFFFAOYSA-N

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相关类别

應用

5′胸苷三磷酸钠盐可用于：
  • 基于多适体氧化石墨烯纳米片复合物的双适体淬灭能力实验和多核苷酸检测
  • 研究大肠杆菌中心代谢中的蛋白质-代谢物相互作用
  • 以AM-toxin为引物，合成聚合物链式反应(PCR)产物

胸腺嘧啶核苷 5′-三磷酸（dTTP）是四种天然脱氧核苷酸之一，与脱氧腺苷 5′-三磷酸（dATP）、脱氧鸟苷 5′-三磷酸（dGTP）和脱氧胞嘧啶 5′-三磷酸（dCTP）一起通过DNA聚合酶和逆转录酶用于脱氧核糖核酸的生物合成。脱氧-TTP 也可用作研究胸苷-三磷酸酶（EC 3.6.1.39）和其他 dTTP 水解活性的特异性和动力学的底物。

生化／生理作用

胸苷三磷酸是DNA的结构单元。可作为其他核苷酸代谢的异构调节蛋白。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Chien-Sung Tsai et al.
American journal of translational research, 8(12), 5338-5353 (2017-01-13)
Eotaxin-2 is a potent chemoattractant. High concentration of eotaxin-2 triggers the inflammation and tumor metastasis. Inhibition of eotaxin-2 may protect experimental atherogenesis although the mechanism is still unclear. Toll-like receptor 4 (TLR4) plays a major role mediating vascular inflammation, which
Felicitas Rataj et al.
Molecular biology of the cell, 27(24), 3841-3854 (2016-10-07)
TPA-inducible sequence 11b/butyrate response factor 1 (TIS11b/BRF1) belongs to the tristetraprolin (TTP) family of zinc-finger proteins, which bind to mRNAs containing AU-rich elements in their 3'-untranslated region and target them for degradation. Regulation of TTP family function through phosphorylation by
Ji Eun Park et al.
PloS one, 12(7), e0181933-e0181933 (2017-07-22)
To determine if perfusion in surgical cavity wall enhancement (SCWE) obtained in early post-treatment MR imaging can stratify time-to-progression (TTP) in glioblastoma. This study enrolled 60 glioblastoma patients with more than 5-mm-thick SCWEs as detected on contrast-enhanced MR imaging after
Zhuangsheng Liu et al.
Journal of magnetic resonance imaging : JMRI, 50(3), 847-857 (2019-02-19)
Lymphovascular invasion (LVI) status facilitates the selection of optimal therapeutic strategy for breast cancer patients, but in clinical practice LVI status is determined in pathological specimens after resection. To explore the use of dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI)-based radiomics
Merel M C Lambregts et al.
PloS one, 14(1), e0208819-e0208819 (2019-01-03)
Blood cultures are considered the gold standard to distinguish bacteremia from non-bacteremic systemic inflammation. In current clinical practice, bacteraemia is considered unlikely if blood cultures have been negative for 48-72 hours. Modern BC systems have reduced this time-to-positivity (TTP), questioning
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