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生物源
human
重組細胞
expressed in E. coli
化驗
≥98% (HPLC)
≥98% (SDS-PAGE)
形狀
lyophilized
分子量
~11.5 kDa
包裝
pkg of 50 μg
儲存條件
avoid repeated freeze/thaw cycles
技術
protein expression: suitable
雜質
endotoxin, tested
NCBI登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... SAA1(6288)
一般說明
人 apo-SAA 是一种 104 氨基酸多肽，其循环主要与高密度脂蛋白 (HDL) 相关。在炎性刺激 24 小时内，血浆中 apo-SAA 水平通常为1-5 μg/ml，增加 500-1000 倍，是这种情况下丰度最高的 HDL apo-脂蛋白。人SAA基因可编码一个 122 氨基酸多肽，其中包含一个 18 氨基酸的 N-末端信号序列。
Research Area: IMMUNO AND CKS
Serum amyloid A (SAA) proteins are a group of apolipoproteins produced in response to cytokines released by activated monocytes/macrophages. SAA is a highly conserved acute-phase protein primarily synthesized by the liver.
Serum amyloid A (SAA) proteins are a group of apolipoproteins produced in response to cytokines released by activated monocytes/macrophages. SAA is a highly conserved acute-phase protein primarily synthesized by the liver.
應用
Apo-血清淀粉样蛋白 A 已用于研究其对巨噬细胞中内脂素表达的影响。
Apo-SAA human has been used to culture and stimulate RAW264.7 macrophages to study its effects on visfatin expression.
生化／生理作用
血清淀粉样蛋白A (SAA) 通常在血液中的浓度为 0.1μM。但在应激情况下，其浓度可增加至 1000 倍。它与几种慢性炎性疾病（如动脉粥样硬化）有关。目前已发现，它可通过促进炎症细胞（特别是单核细胞/巨噬细胞）的趋化性、迁移和粘附，参与炎症反应。还有发现证明，SAA 可诱导多种炎症细胞因子的合成和分泌，如 TNF-α（肿瘤坏死因子-α）、IL-1β（白细胞介素-1β）、MCP-1（单核细胞趋化蛋白-1）和 Lp-PLA2（脂蛋白相关磷脂酶 A2）。
Serum amyloid A (SAA) is an equally sensitive marker for the acute phase as C-reactive protein (CRP). It is the most sensitive non-invasive biochemical indicator for allograft rejection. The function of SAA as a cytokine-like protein has been acknowledged in cell-cell communication and as a feedback mechanism in inflammatory, immunologic, neoplastic, and protective pathways. SAA plays a crucial role in the regulation and potentially the spread of the initial acute phase response.
外觀
无菌过滤，不加添加剂冻干。
重構
在 0.1％ 的乙酸中复溶至 1 μg/ul 浓度。然后可使用其他水性缓冲液稀释该溶液。
打开样品瓶之前需离心。避免反复冻融。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Serum Amyloid a Promotes Visfatin Expression in Macrophages.
Wang S
BioMed Research International (2016)
Kiyoshi Migita et al.
PloS one, 9(5), e96703-e96703 (2014-05-23)
Serum amyloid A (SAA) is an acute phase reactant with significant immunological activities, including effects on cytokine synthesis and neutrophil chemotaxis. Neutrophils can also release cytokines with proinflammatory properties. IL-1β is a key proinflammatory cytokine, the secretion of which is
Shixun Wang et al.
BioMed research international, 2016, 4819327-4819327 (2016-03-24)
Visfatin has been reported to exert an important role in the development of atherosclerosis. However, the mechanism that regulated the expression of Visfatin has not been elucidated yet. This study aimed to investigate the effect of SAA on the regulation
Qian Yan et al.
Cellular signalling, 26(9), 1783-1791 (2014-04-08)
Serum amyloid A (SAA), a major acute-phase protein, has potent cytokine-like activities in isolated phagocytes and synovial fibroblasts. SAA-induced proinflammatory cytokine gene expression requires transcription factors such as NF-κB; however, the associated epigenetic regulatory mechanism remains unclear. Here we report
Lei Sun et al.
European journal of immunology, 44(7), 2153-2164 (2014-04-30)
Interleukin-33 (IL-33), an IL-1 family cytokine and nuclear alarmin, is constitutively expressed in epithelial barrier tissues and human blood vessels. However, little is known about the induced expression of IL-33 in monocytes and macrophages, which are major cytokine-producing cells of
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