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product name
辛-(R)-2HG, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
film
儲存條件
desiccated
顏色
colorless
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
−20°C
應用
辛基-(R)-2羟基戊二酸酯(HG)已被用作胶质母细胞瘤细胞中的膜渗透性致癌代谢物(oncometabolite),用于测试其对NANOG转录因子表达的影响。它还被用作酮戊二酸酯(α-KG)依赖性脱氧酶α的竞争性抑制剂。
生化/生理作用
辛基-(R)-2HG (Octyl-D-2HG) 是肿瘤细胞因 NADP + 依赖性异柠檬酸脱氢酶基因 IDH1 和 IDH2 突变而产生的肿瘤代谢产物 D-2-羟基戊二酸盐 (D-2HG) 的膜渗透前体形式。D-2HG 通过与 α-KG 结合竞争抑制多种 α-酮戊二酸/α-KG-依赖性双加氧酶。通过 Octyl-(R)-2HG 处理 (1-50 mM) 的细胞 D-2HG 传递显示出抑制脱甲基酶活性(~148%H3K9me2 和 ~310%H3K79me2 上调;U-87 mg 中 50 mm)以及因为分别抑制 α-KG-依赖性双加氧酶脯氨酰羟化酶 (PHD) 和胶原脯氨酰-4-羟化酶 (C-P4H)而增加 HIF-1α通过, 降低内皮抑素水平。
準備報告
The density is not reported for this compound. The molecular weight is 260.33. The solubility is tested at 2mg/mL in DMSO, however other sources suggest that it is soluble in DMSO up to 10mg/mL.
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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