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product name
铁抑制剂-1, ≥95% (HPLC)
品質等級
化驗
≥95% (HPLC)
形狀
powder
顏色
, faint purple to brown
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
2-8°C
InChI
1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3
InChI 密鑰
UJHBVMHOBZBWMX-UHFFFAOYSA-N
應用
已经确定了铁抑制剂-1在细胞死亡上的抑制效果。
生化／生理作用
铁抑制剂-1是一种活性自由基捕获抗氧化剂，能够捕获过氧自由基，可用作铁死亡的潜在抑制剂。铁死亡被认为是调节性坏死，和细胞凋亡和自吞噬不同。铁抑制剂-1能够保护人们免于亨廷顿病，还能在细胞模型中防止谷氨酸诱导的神经毒性。
铁抑制剂-1是一种高效的非凋亡的，erastin诱导铁死亡细胞死亡抑制剂。铁抑制剂-1能够防止癌症细胞中铁死亡细胞死亡和器官型大鼠脑切片中谷氨酸诱导毒性。铁抑制剂-1控制脂溶解ROS。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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The extracellular pH (pHe) is a key determinant of the cellular (micro)environment and needs to be maintained within strict boundaries to allow normal cell function. Here we used HEK293 cells to study the effects of pHe acidification (24h), induced by
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Ferroptosis is recently reported as a new mode of regulated cell death. It is triggered by disturbed redox homeostasis, overloaded iron and increased lipid peroxidation. Howerver, the role of ferroptosis in hepatic fibrosis remains obscure. In the current study, we
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