化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
運輸包裝
ambient
儲存溫度
2-8°C
SMILES 字串
ON1C(C2CCCCC2)=CC(C)=CC1=O
InChI
1S/C12H17NO2/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10/h7-8,10,15H,2-6H2,1H3
InChI 密鑰
SCKYRAXSEDYPSA-UHFFFAOYSA-N
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生化／生理作用
环吡酮是一种抗真菌和细胞可透过性的铁螯合剂。 研究发现它抑制多种酶和信号通路，包括脯氨酰羟化酶 2（PHD2）、真核翻译起始因子 5A（eIF5A）、Wnt/β-连环蛋白、低氧诱导因子-1α（HIF-1 α）/血管内皮生长因子（ VEGF）、血管内皮生长因子受体 3（VEGFR-3）、雷帕霉素的哺乳动物靶标（mTOR）和细胞周期蛋白依赖性激酶（CDK）。 环吡酮除具有抗真菌活性外，还具有抗病毒和抗癌活性。 研究还表明，环吡酮以 p21 依赖性方式抵消糖尿病小鼠的糖毒性。
环吡酮是属于羟基吡啶酮类的化合物。研究发现它对皮肤癣菌、酵母、霉菌、某些细菌以及耐唑类念珠菌具有活性。与其他可抑制麦角固醇的抗真菌药不同，环吡酮具有不同的作用。它靶向降解真菌细胞过氧化物的金属依赖性酶。环吡酮的这种独特作用使得在病原真菌中抗药性几率较低。这种化合物用于指甲和皮肤特异性的局部配方。
訊號詞
Warning
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
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