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品質等級
化驗
≥95% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 3 mg/mL, clear (warmed)
儲存溫度
2-8°C
SMILES 字串
C1(C2=CC=NC=C2)=NN=C(SC3=NC=NC4=C3SC5=C4C=CC=N5)N1CC6=CC=CC=C6
InChI
1S/C23H15N7S2/c1-2-5-15(6-3-1)13-30-20(16-8-11-24-12-9-16)28-29-23(30)32-22-19-18(26-14-27-22)17-7-4-10-25-21(17)31-19/h1-12,14H,13H2
InChI 密鑰
CBBXTGWSGPEJEE-UHFFFAOYSA-N
應用
TH1020已用于抑制猪肠单层上皮细胞和小鼠中的toll样受体5(TLR5)。
生化／生理作用
TH1020介导肿瘤坏死因子-α(TNF-α)相关信号传导的抑制，它通过结合TLR5二聚体之间的分子界面以破坏四聚体复合物的形成。
TH1020是一种无细胞毒性的无细胞毒性toll样受体5（TLR5）/鞭毛蛋白复合物抑制剂。
TH1020是一种无细胞毒性的无细胞毒性toll样受体5（TLR5）/鞭毛蛋白复合物抑制剂。TH1020可选择地阻止鞭毛蛋白诱导的TLR5信号转导，而不影响配体诱导的TLR2、TLR3、TLR4、TLR7或TLR8的激活。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Lei Yan et al.
ChemMedChem, 11(8), 822-826 (2015-12-05)
Protein-protein interactions have been regarded as "undruggable" despite their importance in many biological processes. The complex formed between host toll-like receptor 5 (TLR5) and flagellin, a globular protein that is the main component of a bacterial flagellum, plays a vital role
Yu Luo et al.
Veterinary research, 50(1), 48-48 (2019-06-22)
Enterotoxigenic Escherichia coli (ETEC) are an important cause of post-weaning diarrhea (PWD) in piglets. The IL-17 cytokine family is well known to play important roles in the host defense against bacterial infections at the mucosa. Previously, we reported the potential
Norimitsu Morioka et al.
Journal of neurochemistry, 150(6), 738-758 (2019-07-06)
Intrathecal treatment with recombinant high-mobility group box-1 (rHMGB1) in naïve mice leads to a persistent and significantly decreased hind paw withdrawal threshold to mechanical stimuli, suggesting that spinal HMGB1 evokes abnormal pain processing. By contrast, repeated intrathecal treatment with anti-HMGB1
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