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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
OC(C=C1)=CC2=C1OC3=C4C(C(OC=C42)=O)=C(O)C=C3
生化／生理作用
Sparstolonin B（SsnB）是一种从黑三棱和荆三棱中分离得到的异香豆素，是一种有效的TLR2和TLR4拮抗剂，具有抗炎和抗病毒（抗HIV）特性。Sparstolonin B在3T3- L1脂肪细胞中可抑制LPS诱导的炎症，并降低高脂饮食喂养的大鼠体重。Sparstolonin B可减轻小鼠模型中非酒精性脂肪性肝炎（NASH）的炎症。
Sparstolonin B（SsnB）是一种多酚。它具有类似于氧杂蒽酮和异香豆素的结构特征。 SsnB对小鼠和人类巨噬细胞具有抗炎效果。 SsnB可通过阻断细胞外信号调节蛋白激酶（ERK1/2）和c-jun N端激酶（JNK）信号通路而显著降低缺氧-再氧合诱导的心肌炎。因此，SsnB可作为治疗心肌缺血再灌注（MIR）损伤的一种有效疗法。
具有抗炎和抗病毒（抗HIV）特性的有效TLR2和TLR4拮抗剂
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Sparstolonin B attenuates hypoxia-reoxygenation-induced cardiomyocyte inflammation
Liu Q, et al.
Exp. Biol. Med, 239(3), 376-384 (2014)
Diptadip Dattaroy et al.
American journal of physiology. Gastrointestinal and liver physiology, 310(7), G510-G525 (2016-01-01)
Although significant research data exist on the pathophysiology of nonalcoholic steatohepatitis (NASH), finding an efficient treatment regimen for it remains elusive. The present study used sparstolonin B (SsnB), a novel TLR4 antagonist derived from the Chinese herb Sparganium stoloniferum, as
Characterization of Sparstolonin B, a Chinese Herb-derived Compound, as a Selective Toll-like Receptor Antagonist with Potent Anti-inflammatory Properties.
Liang Q, et al.
The Journal of Biological Chemistry, 286(30), 26470-26479 (2011)
Ming Wang et al.
European journal of pharmacology, 769, 79-85 (2015-11-03)
Sparstolonin B (SsnB), an isocoumarin compound isolated from the tubers of both Sparganium stoloniferum and Scirpus yagara, has been reported to have anti-inflammatory effects. However, whether SsnB has anti-inflammatory effects on LPS-stimulated 3T3-L1 adipocytes remains unclear. In this study, we
Xin Deng et al.
Virology journal, 12, 108-108 (2015-07-25)
The Chines herb derived Sparstolonin B, (SsnB), is a recently identified natural compound that selectively blocks TLR2- and TLR4-mediated inflammatory signaling. But it is unknown whether this compound has any effect on HIV infection. We found that SsnB treatment blocked
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