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Merck

SML0444

Sigma-Aldrich

Pluripotin

≥98% (HPLC)

别名:

N-[3-[7-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-1-methyl-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide, SC 1, SC-1

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About This Item

经验公式(希尔记法):
C27H25F3N8O2
分子量:
550.54
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 10 mg/mL (clear solution)

儲存溫度

−20°C

SMILES 字串

CN1C(=O)N(Cc2cnc(Nc3cc(C)nn3C)nc12)c4cc(NC(=O)c5cccc(c5)C(F)(F)F)ccc4C

InChI

1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34)

InChI 密鑰

NBZFRTJWEIHFPF-UHFFFAOYSA-N

生化/生理作用

Pluripotin is an activator of murine embryonic stem (ES) cell renewal; Dual RasGAP and ERK1 inhibitor.
Pluripotin is an activator of murine embryonic stem (ES) cell self-renewal. It appears that pluripotin mediates the activity by dual RasGAP and ERK1 inhibition.

特點和優勢

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Ye F Tian et al.
Biomaterials, 73, 110-119 (2015-09-26)
Non-Hodgkin lymphomas are a heterogeneous group of lymphoproliferative disorders of B and T cell origin that are treated with chemotherapy drugs with variable success rate that has virtually not changed over decades. Although new classes of chemotherapy-free epigenetic and metabolic
Franziska Hentzschel et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(12), 2130-2141 (2014-09-06)
Malaria, caused by protozoan Plasmodium parasites, remains a prevalent infectious human disease due to the lack of an efficient and safe vaccine. This is directly related to the persisting gaps in our understanding of the parasite's interactions with the infected

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