所有图片(1)
About This Item
经验公式（希尔记法）:
C23H36N2 · HCl
CAS号:
分子量:
377.01
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.77
推荐产品
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to off-white
溶解度
DMSO: >20 mg/mL
儲存溫度
2-8°C
SMILES 字串
Cl[H].C1CCCCCN=C(CCCCC1)N[C@H]2CCC[C@H]2c3ccccc3
InChI
1S/C23H36N2.ClH/c1-2-4-6-11-18-23(24-19-12-7-5-3-1)25-22-17-13-16-21(22)20-14-9-8-10-15-20;/h8-10,14-15,21-22H,1-7,11-13,16-19H2,(H,24,25);1H/t21-,22-;/m0./s1
InChI 密鑰
CKOPQUCSDBVAQG-VROPFNGYSA-N
應用
MDL-12,330A盐酸盐已用作腺苷酸环化酶抑制剂，抑制间充质干细胞(MSC)中的环磷腺苷信号传导。它也已用作腺苷酸环化酶抑制剂，检测其对悬尾实验(TST)小鼠自主活动的影响。
生化／生理作用
MDL-12,330A是一种环烷基内亚胺(lactamimide)，可用作电压门控钾离子通道阻断剂(KV)，有助于动作电位时程(APD)延长和胰岛素分泌。它也可阻断钙(Ca2+)内流通道。
腺苷酸环化酶抑制剂。
特點和優勢
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Peiyu Xie et al.
International immunopharmacology, 12(1), 158-168 (2011-12-14)
A recombinant complement anaphylatoxin, C4a, inhibited chemotaxis, respiratory burst and histamine release in mast cell-like HMC-1 cells that were treated with recombinant C5a anaphylatoxin. C4a also inhibited histamine release from HMC-1 cells that were induced by recombinant C3a. The inhibition
Michele Dibattista et al.
Journal of neurophysiology, 100(2), 576-586 (2008-05-30)
Hyperpolarization-activated currents (Ih) are present in several neurons of the central and peripheral nervous system. However, Ih in neurons of the vomeronasal organ (VNO) is not well characterized. We studied the properties of Ih in sensory neurons from acute slices
Dong Fu et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(4), 1403-1408 (2011-01-12)
This study describes a unique function of taurocholate in bile canalicular formation involving signaling through a cAMP-Epac-MEK-Rap1-LKB1-AMPK pathway. In rat hepatocyte sandwich cultures, polarization was manifested by sequential progression of bile canaliculi from small structures to a fully branched network.
Layla Al-Nakkash
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30(1), 137-150 (2012-07-05)
Daily subcutaneous injections with the phytoestrogen genistein, 600 mg/ kg genistein/day (600G) significantly increased intestinal chloride (Cl(-)) secretion (I(sc), µA/cm(2)) in C57BL/6J female and male murine jejunum after 1-2-weeks treatment. In 600G females, basolateral application of the adenylate cyclase inhibitor
Kohei Ueno et al.
The European journal of neuroscience, 28(10), 1956-1966 (2008-12-03)
In gustatory receptor neurons (GRNs) in Drosophila melanogaster, Gr5a and one of the Gr64s encode sugar receptors with seven transmembrane domains. Previously, we have shown that the responses to various sugars are depressed in DGsalpha mutant flies (Ueno et al.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门