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P2443

Sigma-Aldrich

Pluronic® F-127

powder, BioReagent, suitable for cell culture

别名:

Non-ionic copolymer surfactant

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About This Item

线性分子式:
(C3H6O·C2H4O)x
CAS号:
9003-11-6
MDL號碼:
MFCD00082049
分類程式碼代碼:
12161902
PubChem物質ID:
24897874
NACRES:
NA.75

描述

Non-ionic
contains 100ppm BHT

品質等級

200

產品線

BioReagent

形狀

powder

分子量

~12600 g/mol

技術

cell culture | mammalian: suitable

CMC

950-1000 ppm (~25°C)

轉變溫度

cloud point >100 °C

HLB

18 - 23

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI 密鑰

RVGRUAULSDPKGF-UHFFFAOYSA-N

相关类别

一般說明

Pluronicpluronic® F-127，也称为泊洛沙姆 407，是一种无毒非离子共聚物。它含有以三嵌段结构排列的聚环氧乙烷-聚环氧丙烷，形成PEO-PPO-PEO对称。这种聚合物的表面活性剂特性来源于其两亲性，使它们能够与疏水表面和生物膜相互作用。

應用

Pluronic® F-127 已用于：

  • 作为肽到伤口部位的递送系统，以研究肽对小鼠伤口愈合的影响。
  • 作为 PDMS（聚二甲基硅氧烷）印章的表面涂层，使其具有水凝胶排斥性。
  • 制备用于测量神经活动的钙指示剂储备溶液。
  • 作为磷酸盐缓冲盐水 (PBS) 的成分，可降低非特异性细胞和蛋白质对基于 PDMS 的微流体装置的粘附。
  • 这种非离子共聚物表面活性剂适合作为消泡剂用于昆虫细胞培养应用。

生化／生理作用

Pluronic® F-127 是一种热可逆凝胶，由于其高热敏性、生物降解性和生物相容性而在不同行业中得到应用。这些特性使该聚合物适合用作多功能药物载体。Pluronic® F-127 通过提高药物的生物利用度和热稳定性来提高药物的治疗效果。此外，它还可以促进细胞附着和胶原蛋白形成，从而促进血管生成和组织再生。由于其功效，Pluronic F-127 已被用于间充质干细胞 (MSC) 的封装，以帮助血管水平低的组织再生，例如上皮组织、脂肪组织、软骨、肌腱和骨组织 。

法律資訊

Pluronic is a registered trademark of BASF

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Philippe Marmottant et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(41), 17271-17275 (2009-10-07)
Cell aggregates are a tool for in vitro studies of morphogenesis, cancer invasion, and tissue engineering. They respond to mechanical forces as a complex rather than simple liquid. To change an aggregate's shape, cells have to overcome energy barriers. If
Federico Ceriani et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(46), E7194-E7201 (2016-11-04)
Spatially and temporally coordinated variations of the cytosolic free calcium concentration ([Ca2+]c) play a crucial role in a variety of tissues. In the developing sensory epithelium of the mammalian cochlea, elevation of extracellular adenosine trisphosphate concentration ([ATP]e) triggers [Ca2+]c oscillations
Annemarie Lüdecke et al.
Nature communications, 9(1), 2214-2214 (2018-06-09)
Form and function of the mitotic spindle depend on motor proteins that crosslink microtubules and move them relative to each other. Among these are kinesin-14s, such as Ncd, which interact with one microtubule via their non-processive motor domains and with
Allen Yi-Lun Tsai et al.
Molecular plant, 12(1), 99-112 (2018-12-07)
Seed exudates influence the behavior of soil organisms, but how this occurs remains unclear, particularly for multicellular animals. Here we show that compounds associated with Arabidopsis seed-coat mucilage regulate the behavior of soil-borne animals, specifically root-knot nematodes (RKNs). Infective RKN
Yukun Sun et al.
EBioMedicine, 46, 133-149 (2019-08-04)
The evaluation for surgical resectability of pancreatic ductal adenocarcinoma (PDAC) patients is not only imaging-based but highly subjective. An objective method is urgently needed. We report on the clinical value of a phenotypic circulating tumor cell (CTC)-based blood test for
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