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Merck
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T3757

Sigma-Aldrich

TTNPB

别名:

4- [(E)-2-（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）-1-丙烯基] 苯甲酸, 芳香烃酸

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About This Item

经验公式（希尔记法）:
C24H28O2
CAS号:
71441-28-6
分子量:
348.48
MDL號碼:
MFCD00673917
分類程式碼代碼:
12352200
PubChem物質ID:
24278733
NACRES:
NA.77

溶解度

ethanol: soluble 10 mM
DMSO: soluble 25 mM
chloroform/methanol: soluble 9.80-10.20 mg/mL, clear, colorless to light yellow

品質等級

200

儲存溫度

−20°C

SMILES 字串

C\C(=C/c1ccc(cc1)C(O)=O)c2ccc3c(c2)C(C)(C)CCC3(C)C

InChI

1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+

InChI 密鑰

FOIVPCKZDPCJJY-JQIJEIRASA-N

基因資訊

human ... RARA(5914) , RARB(5915) , RARG(5916) , RXRA(6256) , RXRB(6257) , RXRG(6258)

應用

已将 TTNPB 用于 293T 细胞的转录分析 4 。它也被用作培养的人脐血 CD34 + CD38 - lin - 细胞 5 的 RAR 激动剂。

生化／生理作用

对视黄酸受体 (RAR) α 具有亲和力的选择性和高效的视黄酸类似物, β和 γ为核转录因子。产生具有视黄酸应答元件的基因的配体激活转录。

特點和優勢

该化合物在受体分类和信号转导手册中 核受体（非甾体化合物） 页面中进行了详细介绍。欲浏览其他手册页面，请 点击这里。

準備報告

TTNPB 溶于 9.80-10.20 mg/mL 的 CHCL3/MeOH (1/1) 中，得到澄清、无色至淡黄色溶液。溶于乙醇 (10 mM) 和 DMSO (25 mM)。

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險分類

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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分析证书(COA)

Lot/Batch Number
109M4008V
068M4065V
016M4006V
045M4044V
13140107

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Olivier M Niemoeller et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 21(1-3), 193-202 (2008-01-23)
Vitamin A and retinoic acid have previously been shown to confer some protection against a severe course of malaria by fostering the phagocytosis of parasitized erythrocytes. Phagocytosis of erythrocytes is stimulated by phosphatidylserine exposure at the cell surface. The present
Matthias W Büttner et al.
Chembiochem : a European journal of chemical biology, 8(14), 1688-1699 (2007-09-05)
Twofold sila-substitution (C/Si exchange) in the saturated ring of the tetrahydronaphthalene skeleton of the retinoid agonists TTNPB (1 a) and 3-methyl-TTNPB (2 a) leads to disila-TTNPB (1 b) and disila-3-methyl-TTNPB (2 b), respectively. The silicon compounds 1 b and 2
Bryan R Haugen et al.
The Journal of clinical endocrinology and metabolism, 89(1), 272-280 (2004-01-13)
Therapy for patients with advanced thyroid carcinoma is limited. Clinical and in vitro studies suggest that some patients with advanced thyroid cancer may respond to therapy with retinoic acid. mRNA expression of the six retinoic acid (RAR) and retinoid X
Karine Hellemans et al.
Hepatology (Baltimore, Md.), 39(1), 97-108 (2004-01-31)
Activation of hepatic stellate cells (HSC) is a central event in the pathogenesis of liver fibrosis during chronic liver injury. We examined the expression of retinoic acid (RAR) and retinoid X receptors (RXR) during HSC activation and evaluated the influence
John S Bertram et al.
Biochimica et biophysica acta, 1740(2), 170-178 (2005-06-14)
Virtually all human tumors are deficient in gap junctional communication (GJC) and the restoration of GJC by forced expression of connexins reduces indices of neoplasia. The expression of connexin 43 (Cx43) is upregulated by cancer-preventive retinoids and carotenoids which correlates
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