跳转至内容
Merck
所有图片(1)

文件

SML0320

Sigma-Aldrich

FR180204

≥98% (HPLC)

别名:

5-(2-苯基-吡唑并[1,5-a]吡啶-3-基)-1H-吡唑并[3,4-c]哒嗪-3-基胺, 5-(2-苯基吡唑并[1,5-a]吡啶-3-基)-1H-吡唑并[3,4-c]吡啶并-3-胺, FR 180204

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C18H13N7
CAS号:
865362-74-9
分子量:
327.34
MDL號碼:
MFCD14585805
分類程式碼代碼:
12352200
PubChem物質ID:
329825325
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

faintly yellow to dark yellow

溶解度

DMSO: ≥10 mg/mL

儲存溫度

2-8°C

SMILES 字串

Nc1n[nH]c2nnc(cc12)-c3c(nn4ccccc34)-c5ccccc5

InChI

1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)

InChI 密鑰

XVECMUKVOMUNLE-UHFFFAOYSA-N

應用

FR180204已被用作ERK抑制剂：
  • 用于阻断细胞外信号调节激酶 (ERK) 以确认同源框B7 (HOXB7) 是否通过 AKT/丝裂原活化蛋白激酶 (MAPK) 信号传导调节迁移和增生过程
  • 作为细胞外信号调节激酶 (ERK) 抑制剂用于研究信号通路抑制剂对分化和细胞牵引力的作用
  • 用于确定这种信号蛋白对于间充质基质细胞(MSC)治疗功效是不是必需的。

生化／生理作用

FR180204是一种有效的细胞渗透性、ATP竞争性ERK1和ERK2抑制剂（促分裂原活化蛋白激酶（MAPK）/细胞外信号调节激酶（ERK）1/2）。
它可用于研究ERK的作用并用于药物开发。

特點和優勢

《受体分类和信号转导》手册的 MAPK 页面有该化合物的介绍。如需浏览其他手册页面，请点击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Substrate stiffness and matrix composition coordinately control the differentiation of liver progenitor cells
Kourouklis AP, et al.
Biomaterials, 99, 82-94 (2016)
HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs
He X, et al.
Oncotarget, 8(1), 1247-1247 (2017)
Yuki Shindo et al.
Nature communications, 7, 10485-10485 (2016-01-21)
The phosphorylation cascade in the extracellular signal-regulated kinase (ERK) pathway is a versatile reaction network motif that can potentially act as a switch, oscillator or memory. Nevertheless, there is accumulating evidence that the phosphorylation response is mostly linear to extracellular
Mario Sechi et al.
Scientific reports, 8(1), 15726-15726 (2018-10-26)
The anti-proliferative activity of dietary flavonoid fisetin has been validated in various cancer models. Establishing its precise mechanism of action has proved somewhat challenging given the multiplicity of its targets. We demonstrated that YB-1 promotes epithelial-to-mesenchymal transition and its inhibition
Maren Bakkebø et al.
BMC immunology, 11, 57-57 (2010-11-26)
Cytokines of the transforming growth factor β (TGF-β) superfamily exert effects on proliferation, apoptosis and differentiation in various cell types. Cancer cells frequently acquire resistance to the anti-proliferative signals of TGF-β, which can be due to mutations in proteins of
查看所有相关文献

商品

MAPKs

We offers many products related to MAPKs for your research needs.

丝裂原活化蛋白激酶(MAPK)

我们可提供许多MAPK相关产品，以满足您的各种研究需求。

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门