product name
LY-294,002 盐酸盐, solid, ≥98% (HPLC)
生物源
microbial (Staphylococcus roseus)
品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
white to off-white
溶解度
DMSO: >5 mg/mL
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
InChI
1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChI 密鑰
CZQHHVNHHHRRDU-UHFFFAOYSA-N
一般說明
LY-294,002盐酸盐是类黄酮化合物槲皮素的衍生物，可引发对磷酸肌醇3-激酶（PI3K）的更高抑制。LY-294,002可抑制巨噬细胞的核因子κB信号传导。它可以提高自噬体蛋白LC3的表达，并促进胃癌 和鼻咽癌细胞的凋亡。LY-294,002可调节动作电位复极化并改善肌细胞收缩性。
應用
LY-294,002盐酸盐已被用于抑制：
- 人肺癌细胞中的磷酸肌醇3-激酶（PI3K）
- 间充质干细胞（MSCs）的自噬。
- 成纤维细胞 心肌细胞中的丝氨酸/苏氨酸特异性蛋白激酶（AKT）信号传导。
生化／生理作用
磷脂酰肌醇3-激酶的特异性细胞渗透性抑制剂。
特點和優勢
该化合物是环核苷酸和激酶磷酸酶生物学研究的特色产品。发现更多环核苷酸和激酶磷酸酶生物学特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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