SML0097

奈韦拉平

• 别名: 11-环丙基-5,11-二氢-4-甲基-6H-二吡啶基[3,2-b:2′,3′-e][1,4] 二氮杂- 6-酮
• 经验公式（希尔记法）: C₁₅H₁₄N₄O
• CAS号: 129618-40-2
• 分子量: 266.30
• MDL號碼: MFCD00866928
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825155
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to tan
• 溶解度: DMSO: ≥22 mg/mL
• 儲存溫度: room temp
• SMILES 字串: CC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
• InChI: 1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
• InChI 密鑰: NQDJXKOVJZTUJA-UHFFFAOYSA-N

说明

應用

Nevirapine has been used as non-nucleoside reverse transcriptase inhibitor in in vitro porcine endogenous retrovirus replication, primary hepatocytes and bone marrow dendritic cells (BMDCs).

生化／生理作用

奈韦拉平是 HIV 逆转录酶（NNRTI）的变构非核苷抑制剂。奈韦拉平抑制野生型 RT 的 K_i 为 200 nM。

Nevirapine interacts with glycine 190 residue of human immuno deficiency virus (HIV-2) reverse transcriptase. It is an antiretroviral drug which increases bile synthesis and activates electron transport chain. Use of nevirapine leads to liver toxicity and is associated with Nevirapine hypersensitivity syndrome.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable