推荐产品
用途
sufficient for 100 fluorometric tests
檢測方法
fluorometric
相關疾病
neurological disorders
儲存溫度
−20°C
基因資訊
human ... MAOA(4128) , MAOB(4129)
mouse ... MAOA(17161) , MAOB(109731)
rat ... MAOA(29253) , MAOB(25750)
一般說明
单胺氧化酶 (MAO，EC 1.4.3.4) 是一类可催化单胺氧化脱氨反应的线粒体酶。在哺乳动物中，MAO 由 MAO-A 和 MAO-B 两种同工酶组成。 MAO功能障碍被认为是造成许多神经系统疾病的原因。 体内 MAO 水平过高或过低与抑郁症、精神分裂症、药物滥用、注意力缺陷障碍、偏头痛和不规律性成熟有关。MAO 抑制剂是治疗抑郁症的主要处方药之一。
應用
单胺氧化酶活性测定试剂盒已用于评估 MAO-A（单胺氧化酶 A）、MAO-B（单胺氧化酶 B） 和 ALDH（乙醛脱氢酶）活性。
特點和優勢
兼容高通量的操作系统。
適合性
可用于测定生物样品中的MAO 活性以及筛选MAO 抑制剂。可分别测定MAO-A 和 MAO-B的活性或同时测定两者的活性。
原則
单胺氧化酶测定试剂盒为测定生物样品中 MAO 酶活性提供了一种方便的荧光测定法。在试验中，MAO 与 对酪胺（MAO-A 和 MAO-B 的底物）反应，生成 H 2 O 2 ，可通过荧光法（λex = 530/λ em = 585 nm）测定。该测定方法简便、灵敏、稳定、且具有高通量适应性。单位定义：在测定条件下，一个单位的MAO每分钟催化形成1μ摩尔H 2 O 2 。
儲存類別代碼
10 - Combustible liquids
Lovedeep Singh et al.
Metabolic brain disease, 36(1), 111-121 (2020-09-02)
Pain and depression are often co-existing pathological states that promote mutual severity resulting in limited efficacy of current treatment strategies. Thus, there is a need to develop an efficacious alternate treatment regimen for pain-depression dyad. Skimmetin and osthole are molecules
Proteome Profiling of Primary Pancreatic Ductal Adenocarcinomas Undergoing Additive Chemoradiation Link ALDH1A1 to Early Local Recurrence and Chemoradiation Resistance.
Oria V O, et al.
Translational Oncology, 11(6), 1307-1322 (2018)
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats.
Renko J M, et al.
Molecular Neurobiology, 1-14 (2018)
Juho-Matti Renko et al.
Molecular neurobiology, 55(8), 6755-6768 (2018-01-20)
Neurotrophic factors (NTFs) hold potential as disease-modifying therapies for neurodegenerative disorders like Parkinson's disease. Glial cell line-derived neurotrophic factor (GDNF), cerebral dopamine neurotrophic factor (CDNF), and mesencephalic astrocyte-derived neurotrophic factor (MANF) have shown neuroprotective and restorative effects on nigral dopaminergic
Begum Evranos-Aksoz et al.
Combinatorial chemistry & high throughput screening, 20(6), 461-473 (2017-05-06)
Depression is a momentous disease that can greatly reduce the quality of life and cause death. In depression, neurotransmitter levels such as serotonine, dopamine and noradrenaline are impaired. Monoamine oxidases (MAO) are responsible for oxidative catalysis of these monoamine neurotransmitters.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门