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MAK021

Sigma-Aldrich

高灵敏度葡萄糖-6-磷酸检测试剂盒

sufficient for 100 fluorometric tests

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About This Item

EC號碼:
222-938-1
分類程式碼代碼:
12161503
NACRES:
NA.84

用途

sufficient for 100 fluorometric tests

檢測方法

fluorometric

相關疾病

cancer; hematological disorder

儲存溫度

−20°C

一般說明

葡萄糖-6-磷酸(G6P)是进入葡萄糖代谢途径和储存的关键代谢中间体。在细胞中，当葡萄糖被己糖激酶或葡萄糖激酶磷酸化，或在糖原分解过程中磷酸葡萄糖变位酶将1-磷酸葡萄糖转化时，会生成G6P。G6P 位于糖酵解和磷酸戊糖途径的起始阶段。当血糖水平高时，它也可以作为糖原储存。葡萄糖-6-磷酸脱氢酶催化 G6P 脱氢，生成 NADPH 形式的还原当量。这在 G6PDH 缺乏导致溶血性贫血的红细胞中尤为重要。葡萄糖-6-磷酸检测试剂盒是一种定量各种样品中 G6P 的简单、灵敏、快速的方法。

特點和優勢

与高通量处理系统兼容。

適合性

适用于测定多各种样品中的葡萄糖-6-磷酸盐浓度。

原則

该试剂盒通过酶法测定葡萄糖-6-磷酸的浓度，该方法产生与 G6P 浓度成正比的荧光(λex = 535 nm/λem = 587 nm)产物。该试剂盒的典型检测灵敏度为100-500 pmole。葡萄糖-6-磷酸检测试剂盒的灵敏度远高于葡萄糖-6-磷酸盐比色检测试剂盒（MAK014），适用于低浓度葡萄糖-6-磷酸的样品。

取代透過

产品编号
说明
价格

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

188.6 °F - closed cup

閃點（°C）

87 °C - closed cup

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Role of the liver in the control
of carbohydrate and lipid homeostasis
Postic C, et al.
Diabete & Metabolisme, 30, 398-408 (2004)
Glucose 6-phosphate dehydrogenase deficiency: from genotype to phenotype.
Lucio L.
The Hematology Journal : The Official Journal of the European Haematology Association / EHA, 1303-1306 (2006)
Glucose-6-phosphate dehydrogenase, NADPH, and cell survival.
Robert C S.
IUBMB Life, 64(5), 362-369 (2012)
Qiuhua Yang et al.
Nature communications, 9(1), 4667-4667 (2018-11-09)
Increased aerobic glycolysis in endothelial cells of atheroprone areas of blood vessels has been hypothesized to drive increased inflammation and lesion burden but direct links remain to be established. Here we show that endothelial cells exposed to disturbed flow in

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