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Merck

M4659

Sigma-Aldrich

米力农

≥97% (TLC), powder, phosphodiesterase type III inhibitor

别名:

1,6-二氢-2-甲基-6-氧-(3,4′-联吡啶)-5-甲腈

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About This Item

经验公式(希尔记法):
C12H9N3O
CAS号:
分子量:
211.22
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.77

product name

米力农, ≥97% (TLC), powder

品質等級

化驗

≥97% (TLC)

形狀

powder

顏色

off-white

溶解度

DMSO: >10 mg/mL
H2O: insoluble

起源

Sanofi Aventis

儲存溫度

2-8°C

SMILES 字串

CC1=C(C=C(C#N)C(=O)N1)c2ccncc2

InChI

1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)

InChI 密鑰

PZRHRDRVRGEVNW-UHFFFAOYSA-N

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生化/生理作用

磷酸二酯酶 Ⅲ 型抑制剂;cAMP 特异性、cGMP 抑制性;强心、正性肌力血管扩张剂。

特點和優勢

该化合物是受体分类及信号转导手册上磷酸二酯酶页面上的特色化合物。想要浏览手册的其他页面, 请单击此处
该化合物是环核苷酸研究推荐产品。点击此处 ,查看更多环核苷酸精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息,请访问 sigma.com/discover-bsm
该化合物是由 Sanofi Aventis开发。浏览其他由制药公司开发的化合物以及批准药物/候选药物清单, 请单击此处

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


分析证书(COA)

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Melike Bayram et al.
The American journal of cardiology, 96(6A), 47G-58G (2005-09-27)
The appropriate role of intravenous inodilator therapy (inotropic agents with vasodilator properties) in the management of acute heart failure syndromes (AHFS) has long been a subject of controversy, mainly because of the lack of prospective, placebo-controlled trials and a lack
Baozeng Xu et al.
Developmental biology, 385(2), 242-252 (2013-11-20)
The oocyte becomes competent for embryonic development by involving mutual communication with cumulus cells (CCs) during folliculogenesis. How this communication takes place under physiological conditions is not fully understood. Current study examined oocyte-CCs communication in the XY sex-revered female mouse.
Neil Patel
Neonatology, 102(2), 130-136 (2012-06-20)
Pulmonary hypertension and secondary cardiac dysfunction are important contributors of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). Milrinone, a phosphodiesterase-3 inhibitor, may be useful in this setting for its combined actions as a pulmonary vasodilator and to
Yuichiro Miura et al.
Pediatric research, 72(5), 490-494 (2012-08-14)
Previous studies aimed at developing an artificial placenta have had limited success. We hypothesized that the introduction of a high-performance membranous oxygenator to a pumpless artificial placenta could prolong the survival time of premature lambs. Immediately after delivery of the
Patrick J McNamara et al.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 14(1), 74-84 (2012-11-08)
Persistent pulmonary hypertension of the newborn is a common problem with significant morbidity and mortality. Inhaled nitric oxide is the standard care, but up to 40% of neonates are nonresponders. Milrinone is a phosphodiesterase III inhibitor which increases the bioavailability

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