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Key Documents

L4130

Sigma-Aldrich

脂多糖 来源于大肠杆菌 0111:B4

purified by trichloroacetic acid extraction

别名:

LPS

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About This Item

EC號碼:
MDL號碼:
分類程式碼代碼:
12352201
NACRES:
NA.25

生物源

Escherichia coli (O111:B4)

品質等級

形狀

lyophilized powder

純化經由

trichloroacetic acid extraction

雜質

1-10% Protein (Lowry)

顏色

white to light yellow

溶解度

water: soluble

運輸包裝

ambient

儲存溫度

2-8°C

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一般說明

本品是从大肠杆菌血清型O111:B4中提取的TCA。来源菌株由私人提供。该LPS血清型已被用于刺激B细胞并诱导人肝细胞的NOS。

應用

脂多糖(LPS)是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式(PAMP)的Toll样受体蛋白家族成员Toll样受体4(TLR4)刺激先天性免疫系统细胞。

生化/生理作用

脂多糖(LPS)位于膜的外层,并且暴露在无包膜菌株的细胞表面。它们有助于维持外层膜的完整性,并保护细胞免受胆汁盐和亲脂性抗生素的破坏。

準備報告

本品溶于水(5 mg/ml)或细胞培养基(1 mg/ml),得到浑浊的淡黄色溶液。以盐水为溶剂时,经过涡旋并加热至70-80 oC后,得到浓度更高但仍然浑浊的溶液(20 mg/ml)。脂多糖分子可在各种溶剂中形成胶束。在水和磷酸盐缓冲盐水中,可观察到浑浊的溶液。使用有机溶剂不会得到更澄清的溶液。以甲醇为溶剂将得到含漂浮物的混浊悬浮液,而以水为溶剂将得到均匀的混浊溶液。

其他說明

为了全面了解我们针对客户研究提供的各种脂多糖产品,建议您访问我们的碳水化合物分类页面。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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