推荐产品
生物源
Escherichia coli (O111:B4)
品質等級
無菌
γ-irradiated
產品線
BioXtra
形狀
lyophilized powder
純化經由
gel-filtration chromatography
儲存條件
desiccated
技術
cell based assay: suitable
cell culture | mammalian: suitable
雜質
<1% Protein (Lowry)
溶解度
H2O: 5 mg/mL, slightly hazy
應用
clinical research
life science and biopharma
儲存溫度
2-8°C
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一般說明
脂多糖 (LPS) 是由脂质和多糖组成的复杂分子，主要存在于革兰氏阴性菌的外膜中。LPS 由脂质 A、核心低聚糖 (core) 和 O 特异性多糖或 O 抗原 (Oag) 组成，固定在细菌外膜上，脂质 A 主要负责其相关毒性。作为促炎反应的有效激活剂，LPS 参与多种哺乳动物细胞，包括巨噬细胞、单核细胞和内皮细胞。在保护革兰氏阴性菌免受环境胁迫的同时，LPS 也在感染过程中触发先天免疫系统的识别。
應用
该LPS血清型已用于刺激B细胞并在人肝细胞中诱导NOS。
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。
生化／生理作用
脂多糖是绝大多数革兰氏阴性菌细胞壁的一种主要组成成分。它是一种高免疫原性抗原，具有增强针对可溶性抗原免疫应答的能力。LPS还可作为来自小鼠、兔、鸡、牛、仓鼠和人骨髓来源的B淋巴细胞的一种特异性促分裂原。
特點和優勢
- 高纯度化合物适用于各种研究应用
重構
脂多糖以经γ-射线处理的冻干粉形式提供。如需重悬，可将1 ml无菌的平衡盐溶液或组织培养基加入至小瓶（1 mg）中并轻轻晃动直至粉末溶解。重悬后的产品可采用无菌的平衡盐溶液或组织培养基进一步被稀释至所需的工作浓度。
相關產品
产品编号
说明
价格
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 2 Oral
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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