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Merck

D5287

Sigma-Aldrich

2′-脱氧肌苷

≥98%

别名:

9-(2-脱氧-β-D-呋喃核糖基)次黄嘌呤

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About This Item

经验公式(希尔记法):
C10H12N4O4
CAS号:
分子量:
252.23
Beilstein:
33517
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

生物源

synthetic (organic)

化驗

≥98%

形狀

powder

雜質

inosine, essentially free

溶解度

1 M NH4OH: 50 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3C(=O)NC=Nc23

InChI

1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1

InChI 密鑰

VGONTNSXDCQUGY-RRKCRQDMSA-N

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應用

2′-脱氧肌苷已被用于通过液相色谱串联质谱(LC-MS/MS)对单个DNA样品中的核苷形式DNA损伤进行定量。它也被用作高效液相色谱分析的标准品。

生化/生理作用

2′-脱氧肌苷是一种由次黄嘌呤通过β-N9-糖苷键与2′-脱氧核糖连接而组成的核苷。DNA中的2′-脱氧肌苷可来自于腺苷的脱氨作用。2′-脱氧肌苷可作为模型化合物用于研究可能影响DNA结构的加合物形成和自由基化学。2′-脱氧肌苷可用于产生具有自我回避能力的杂交敏感型荧光DNA探针。
2′-脱氧肌苷是次黄嘌呤的一种核苷形式。它是由活性氮引起的DNA损害的一种DNA损伤产物。2′-脱氧肌苷是通过N2O3由亚硝化脱氨而形成的。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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The human endonuclease V gene is located in chromosome 17q25.3 and encodes a 282 amino acid protein that shares about 30% sequence identity with bacterial endonuclease V. This study reports biochemical properties of human endonuclease V with respect to repair
A Cohen et al.
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To delineate the normal function of purine nucleoside phosphorylase and to understand the pathogenesis of the immune dysfunction associated with deficiency of this enzyme, we studied purine metabolism in a patient deficient in purine nucleoside phosphorylase, her erythrocytes and cultured

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