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生物源
synthetic (organic)
品質等級
化驗
≥98.5%
形狀
powder
雜質
Thymidine, free
溶解度
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
SMILES 字串
OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O
InChI
1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1
InChI 密鑰
MXHRCPNRJAMMIM-SHYZEUOFSA-N
基因資訊
mouse ... Slc29a1(63959)
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應用
2′-脱氧尿苷已用于:
- 代替胸苷用作[3H]胸苷三磷酸 (TTP)前体,避免在相对增殖测定中潜在的胸苷阻断
- 用作核苷补充剂,以进行细胞周期同步和DNA复制抑制
- 用作培养基中的有丝分裂抑制剂,最大限度减少神经胶质细胞增殖
生化/生理作用
2′-脱氧尿苷(dU)经常被卤化,生成用于DNA合成和降解机制研究的胸苷激酶类似物。作为标记底物的衍生2′-脱氧尿苷包括氯-2′-脱氧尿苷(CldU)、溴脱氧尿苷(BrdU)和/或碘脱氧尿苷(IdU)。其他有用的2′-脱氧尿苷类似物包括5-乙基-2′-脱氧尿苷(DdU)和5-羟基甲基-2′-脱氧尿苷(HmdU)。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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Alkyne has a unique Raman band that does not overlap with Raman scattering from any endogenous molecule in live cells. Here, we show that alkyne-tag Raman imaging (ATRI) is a promising approach for visualizing nonimmobilized small molecules in live cells.
Cytotherapy, 15(1), 57-63 (2012-12-25)
Thymidine analog 5-ethynyl-2-deoxyuridine (EdU) has recently been used for tracking mesenchymal stem cells (MSCs). In the present study, we tested whether EdU was cytotoxic and whether it interfered with differentiation, cytokine secretion and migration of MSCs. EdU labeling was performed
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Therapeutic small interfering RNAs (siRNAs) are composed of chemically modified nucleotides, which enhance RNA stability and increase affinity in Watson-Crick base pairing. However, the precise fate of such modified nucleotides once the siRNA is degraded within the cell is unknown.
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