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Merck

D7400

Sigma-Aldrich

2'-脱氧腺苷 一水合物

≥99%

别名:

9-(2-脱氧-β- D -呋喃核糖基)腺嘌呤, 腺嘌呤脱氧核苷

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About This Item

经验公式(希尔记法):
C10H13N5O3 · H2O
CAS号:
分子量:
269.26
Beilstein:
91015
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

生物源

synthetic (organic)

品質等級

化驗

≥99%

形狀

powder

溶解度

water: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow

儲存溫度

2-8°C

SMILES 字串

[H]O[H].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3

InChI

1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1

InChI 密鑰

OLXZPDWKRNYJJZ-RRKCRQDMSA-N

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應用

2′-脱氧腺苷一水合物用于:
  • 作为核苷补充品成分
  • 作为标准品,估算增殖油棕胚性悬浮液中的DNA总甲基化率
  • 逆转无菌α基序(SAM)和含组氨酸-天冬氨酸(HD)结构域的蛋白(SAMHD1)
  • 抑制人类免疫缺陷病毒(HIV-1)和乙型肝炎病毒(HBV)

生化/生理作用

2′-脱氧腺苷(2′-dAdo),是脱氧核糖核苷,在能量应激的情况下可能被某些细胞用作能源,影响 cAMP的水平。 2′-dAdo 用于腺苷类似物在各种生物过程中功能的比较研究。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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M Nakamura et al.
The Journal of biological chemistry, 257(23), 13945-13950 (1982-12-10)
Regulation of glucose metabolism in glycolysis by round spermatids was studied. Assay of activities of 11 glycolytic enzymes in cell-free spermatid extracts showed that hexokinase, phosphofructokinase, and glyceraldehyde-3-phosphate dehydrogenase had the lowest activities. When the cells were incubated with glucose
Sonya M Schuh et al.
Biology of reproduction, 77(6), 960-969 (2007-09-01)
Activation of rapid motility apparently is one of the first steps of sperm capacitation and can be studied in vitro. Previously we found that 2-chloro-2'-deoxyadenosine or the catecholamine isoproterenol activates mouse sperm motility in vitro via a pathway mediated by
Michela Giannecchini et al.
The international journal of biochemistry & cell biology, 37(4), 797-808 (2005-02-08)
In this paper, we report that cells undergoing metabolic stress conditions may use the ribose moiety of nucleosides as energy source to slow down cellular damage. In fact, the phosphorolytic cleavage of the N-glycosidic bond of nucleosides generates, without energy
Don E Farthing et al.
Scientific reports, 7(1), 4043-4043 (2017-06-24)
Deuterated water (
SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-kappaB Activation
Kim ET, et al.
Testing, 28(2), 434-448 (2019)

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