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C6643

Sigma-Aldrich

氯贝丁酯

liquid

别名:

氯贝特

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About This Item

经验公式（希尔记法）:
C12H15ClO3
CAS号:
637-07-0
分子量:
242.70
Beilstein:
1913459
EC號碼:
211-277-4
MDL號碼:
MFCD00000615
分類程式碼代碼:
12352200
PubChem物質ID:
24278085
NACRES:
NA.77

形狀

liquid

顏色

clear colorless

密度

1.14 g/mL at 25 °C (lit.)

起源

Wyeth

儲存溫度

2-8°C

SMILES 字串

CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1

InChI

1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3

InChI 密鑰

KNHUKKLJHYUCFP-UHFFFAOYSA-N

基因資訊

human ... PPARA(5465)
mouse ... Ppara(19013)

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應用

Clofibrate has been used:
  • as a quinolinate phosphoribosyltransferase (QPRT) agonist to study its effects on hepatitis C virus (HCV) infection
  • as peroxisome proliferated activated receptor (PPAR) agonist to study its effects on autophagy in rat liver cells
  • as a hepatotoxicant to study its effects on gene expression in primary rat hepatocytes

生化／生理作用

Clofibrate is a peroxisome proliferated activated receptor α (PPARα) agonist. It is a fibric acid derivative and has a therapeutic effect on hypertriglyceridemia and hyperlipoproteinemia type III. Clofibrate participates in lowering the very-low-density lipoprotein (VLDL) and cholesterol levels in hyperlipoproteinemia type III patients. It facilitates the decrease of total serum bilirubin concentration in Gilbert′s syndrome.

特點和優勢

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

象形圖

CorrosionExclamation mark
GHS05,GHS07

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 3

閃點（°F）

235.4 °F - closed cup

閃點（°C）

113 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

分析证书(COA)

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Drug treatment of lipid disorders.
R H Knopp
The New England journal of medicine, 341(7), 498-511 (1999-08-12)
K Nadira De Abrew et al.
Toxicology, 328, 29-39 (2014-12-06)
High-content data have the potential to inform mechanism of action for toxicants. However, most data to support this notion have been generated in vivo. Because many cell lines and primary cells maintain a differentiated cell phenotype, it is possible that
Toshio Morikawa et al.
Journal of natural products, 71(5), 828-835 (2008-03-28)
The methanolic extract and its saponin fraction (methanol-eluted fraction) of the flowers of Bellis perennis were found to suppress serum triglyceride elevation in olive oil-treated mice. From the saponin fraction, seven new triterpene saponins, perennisosides I (1), II (2), III
Masayuki Yoshikawa et al.
Journal of natural products, 68(9), 1360-1365 (2005-09-27)
The methanolic extract and its n-butanol-soluble fraction from the flowers of the tea plant (Camellia sinensis) were found to suppress serum triglyceride elevation in olive oil-treated mice. From the n-butanol-soluble fraction, three new acylated oleanane-type triterpene oligoglycosides, floratheasaponins A-C (1-3)
Sara Chuang et al.
Journal of medicinal chemistry, 52(17), 5344-5355 (2009-08-12)
Liver-fatty acid binding protein (L-FABP) is found in high levels in enterocytes and is involved in cytosolic solubilization of fatty acids. In addition, L-FABP has been shown to bind endogenous and exogenous lipophilic compounds, suggesting that it may also play
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