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C2020

Sigma-Aldrich

α-氰基-4-羟基肉桂酸

≥98% (TLC), powder, monocarboxylic acid transport inhibitor

别名:

α-CCA, α-CHCA, α-氰基, 4-HCCA, ACCA

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About This Item

线性分子式:
HOC6H4CH=C(CN)CO2H
CAS号:
28166-41-8
分子量:
189.17
Beilstein:
3271427
EC號碼:
248-879-1
MDL號碼:
MFCD00004204
分類程式碼代碼:
12352106
PubChem物質ID:
24892459
NACRES:
NA.77

product name

α-氰基-4-羟基肉桂酸, ≥98% (TLC), powder

品質等級

300

化驗

≥98% (TLC)

形狀

powder

顏色

yellow

mp

245-250 °C (lit.)

溶解度

H2O: slightly soluble
methanol: water: soluble
polar organic solvents: soluble

儲存溫度

2-8°C

SMILES 字串

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

InChI 密鑰

AFVLVVWMAFSXCK-VMPITWQZSA-N

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應用

α5-氰基-4-羟基肉桂酸已被用于阻断单羧酸盐转运蛋白。
α5-氰基-4-羟基肉桂酸是用于基质辅助激光解吸/电离飞行时间（MALDI-TOF）质谱的一种有用的疏水性基质溶液。将其用作基质溶液，成功地分析了抗生素、肽核酸（一类新的DNA模拟物）和质量高达66,000 Da的蛋白。

生化／生理作用

α-氰基-4-羟基肉桂酸可充当一元羧酸转运的特异性抑制剂，包括乳酸和丙酮酸的转运。据报道，其还可阻断β-细胞顶端阴离子交换（IC50 为2.4 mM）。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H317

危險分類

Skin Sens. 1B

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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J P Barnard et al.
The Journal of biological chemistry, 268(5), 3654-3661 (1993-02-15)
The protozoan parasite Trypanosoma brucei derives its metabolic energy exclusively from a unique type of glycolysis in which pyruvate derived from glucose catabolism is released into the host bloodstream. In this study, this terminal metabolic step has been examined in
L-Lactate Promotes Adult Hippocampal Neurogenesis
Lev-Vachnish Y, et al.
Frontiers in Neuroscience, 13 (2019)
E T Sze et al.
Journal of the American Society for Mass Spectrometry, 9(2), 166-174 (1998-07-29)
We report a simple method for converting solid matrices into useful matrix solutions for matrix-assisted laser desorption/ionization (MALDI). This method is based on the dissolution of the solid matrix in a liquid support of low volatility such as glycerol. An
C Emmons
The American journal of physiology, 276(4 Pt 2), F635-F643 (1999-04-13)
To functionally characterize transport properties of the apical anion exchanger of rabbit beta-intercalated cells, the mean change in anion exchange activity, dpHi/dt (where pHi is intracellular pH), was measured in response to lumen Cl- replacement with gluconate in perfused cortical
Y C Ling et al.
Rapid communications in mass spectrometry : RCM, 12(6), 317-327 (1998-04-16)
Comparative studies of the matrix-assisted laser desorption/ionization (MALDI) of 30 antibiotics were made using alpha-cyano-4-hydroxycinnamic acid (HCCA), 2,5-dihydroxybenzoic acid (DHB), 5,10,15,20-tetrakis(4-hydroxyphenyl)-21H,23H-porphyrin and meso-tetra(N-methyl-4-pyridyl)porphyrin matrices. Most antibiotics generated intense protonated molecules in HCCA and DHB matrices, and sodium or potassium adduct
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