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About This Item
经验公式（希尔记法）:
C29H36BrN3O6
CAS号:
分子量:
602.52
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77
推荐产品
形狀
powder
品質等級
顏色
yellow
溶解度
ethanol: 20 mg/mL
DMSO: soluble
儲存溫度
2-8°C
SMILES 字串
CNc1c(Br)cc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(O)=O
InChI
1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1
InChI 密鑰
LDXQFZZGVTWFCF-FHYGWRBKSA-N
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應用
4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca2+/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.
非荧光Ca2+离子载体，可用于通过荧光探针校准细胞质游离Ca2+的定量。
生化／生理作用
4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.
其他說明
Analog of calcium ionophore A23187
訊號詞
Warning
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons.
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Neuron, 94(1), 37-47 (2017)
Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro.
Whyte MK, et al.
The Journal of Clinical Investigation, 92(1), 446-455 (1993)
S D Bird et al.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 18(6), 626-636 (1999-02-05)
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A K Kiemer et al.
Immunology and cell biology, 79(1), 11-17 (2001-02-13)
Atrial natriuretic peptide (ANP) attenuates LPS-induced inducible nitric oxide synthase (iNOS) expression in murine macrophages by destabilizing iNOS mRNA. Because elevated intracellular free Ca2+ levels [Ca2+]i reduce iNOS mRNA stability, the aim of the present study was to determine whether
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