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About This Item
经验公式（希尔记法）:
C29H37N3O6
CAS号:
分子量:
523.62
Beilstein:
1096801
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.32
推荐产品
無菌
non-sterile
品質等級
化驗
≥98% (TLC)
形狀
powder
顏色
white to light yellow
溶解度
ethanol: 5 mg/mL
DMSO: 50 mg/mL
抗生素活性譜
Gram-positive bacteria
fungi
作用方式
cell membrane | interferes
儲存溫度
2-8°C
SMILES 字串
[H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
InChI
1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
InChI 密鑰
HIYAVKIYRIFSCZ-CYEMHPAKSA-N
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一般說明
钙离子载体A23187是一种羧酸类抗生素，在体外抗革兰氏阳性菌的活性较弱。它可增加二价离子穿过生物膜的电位，因此起到离子载体的作用。钙离子载体A23187特异性地与二价阳离子形成稳定的2:1复合物，使这些离子可溶于普通有机溶剂。由于钙离子载体A23187通常用于增加完整细胞内的Ca2+水平，它可用作氧化磷酸化的解偶联剂和线粒体腺苷三磷酸酶（ATPase）活性的抑制剂。钙离子载体A23187是弓形虫真核起始因子-2α（eIF2α）磷酸化作用的有效诱导物。此外，它不仅在小鼠淋巴瘤系（S49）7中诱导凋亡；还显示出可以阻断其他系统中的凋亡，例如当白介素3（IL-3）从IL-3依赖性细胞中除去时。钙离子载体A23187广泛用作人卵母细胞的人工辅助激活物。
with heating or sonication. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.
with heating. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.
應用
离子载体对Ca2+具有高度选择性。 增强对NMDA的反应，而不是使君子氨酸。 在细胞培养中，通过钙调素依赖的构成型一氧化氮合酶刺激一氧化氮的产生。
钙离子载体A23187已：
- 用作内质网（ER）应激诱导剂，以研究其对弓形虫未折叠蛋白反应（UPR）基因表达的影响
- 用于诱导顶体反应
- 用于骨骼肌肌浆网Ca2+ATPase (SERCA)的活性测定
也與該產品經常一起購買
产品编号
说明
价格
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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