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Merck

30020

Sigma-Aldrich

D-环丝氨酸

别名:

(R)-4-氨基-3-异噁唑烷酮, 4-氨基-3-异噁唑烷酮

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About This Item

经验公式(希尔记法):
C3H6N2O2
CAS号:
分子量:
102.09
Beilstein:
80798
EC號碼:
MDL號碼:
分類程式碼代碼:
51102829
PubChem物質ID:
NACRES:
NA.85

生物源

synthetic

品質等級

形狀

powder

效力

≥900 μg per mg

顏色

white to off-white

mp

147 °C (dec.) (lit.)

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

作用方式

cell wall synthesis | interferes

儲存溫度

−20°C

SMILES 字串

N[C@@H]1CONC1=O

InChI

1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1

InChI 密鑰

DYDCUQKUCUHJBH-UWTATZPHSA-N

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一般說明

Chemical structure: amino acid derivatives

應用

D-Cycloserine acts as inhibitor of various enzymes.

生化/生理作用

Mode of Action: Inhibits cell wall biosynthesis (D-Ala peptide bond formation). Also prevents conversion of D-Ala to L-Ala. Bacteriostatic. Mode of Resistance: D-Ala transport interference.
作用方式:抑制细胞壁生物合成(D-Ala 肽键形成)。同时可防止将D-Ala转化为L-Ala。抑菌性。
作用于 NMDA 谷氨酸能受体的甘氨酸调节位点的部分激动剂;抗革兰氏阴性细菌的抗生素。
干预方式:D-Ala转运干预。

包裝

1g, 5g, 25g

其他說明

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Air sensitive. Keep in a dry place.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Michael L Sulkowski et al.
Current psychiatry reviews, 10(4), 317-324 (2014-11-11)
Variants of exposure therapy are effective for treating obsessive-compulsive and related disorders (OCRDs). However, significant numbers of patients do not respond adequately to exposure therapy resulting in continued distress and functional impairment. Therefore, novel approaches to augmenting exposure therapy are
M.K. Jain
Handbook of Enzyme Inhibitors, 112-112 (1982)
Marta Portero-Tresserra et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 24(11), 1798-1807 (2014-12-03)
Previous research has demonstrated that systemic D-cycloserine (DCS), a partial agonist of the N-methyl-D-aspartate receptor (NMDAR), enhances memory processes in different learning paradigms and attenuates mnemonic deficits produced by diverse pharmacological manipulations. In the present study two experiments were conducted
Stefan G Hofmann et al.
Current psychiatry reports, 17(1), 532-532 (2014-11-22)
Although cognitive behavioral therapy (CBT) is a generally effective treatment for treating anxiety disorders, there is clearly still room for further improvements. Recent advances in neuroscience of extinction learning led to novel clinical strategies to augment exposure-based treatments with d-cycloserine
Simon P Byrne et al.
Depression and anxiety, 32(6), 408-414 (2015-03-17)
For exposure therapy to be successful, it is essential that fear extinction learning extends beyond the treatment setting. D-cycloserine (DCS) may facilitate treatment gains by increasing generalization of extinction learning, however, its effects have not been tested in children. We

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