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Merck

PHR1345

Supelco

齐多夫定相关化合物C

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

胸腺嘧啶, 2,4-二羟基-5-甲基嘧啶, 5-甲基尿嘧啶

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About This Item

经验公式(希尔记法):
C5H6N2O2
CAS号:
分子量:
126.11
Beilstein:
117880
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to USP 1754532

API 家族

zidovudine

CofA

current certificate can be downloaded

技術

HPLC: suitable
gas chromatography (GC): suitable

mp

~320 °C (dec.) (lit.)

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-30°C

SMILES 字串

CC1=CNC(=O)NC1=O

InChI

1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)

InChI 密鑰

RWQNBRDOKXIBIV-UHFFFAOYSA-N

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一般說明

Thymine (Zidovudine Related Compound C) is a process related impurity of antiretroviral drug zidovudine. Zidovudine belongs to the class of drugs known as nucleoside reverse transcriptase inhibitors and is generally used in the prevention and treatment of HIV/AIDS.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

應用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Thymine (Zidovudine Related Compound C) may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.

分析報告

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAA1097 in the slot below. This is an example certificate only and may not be the lot that you receive.

推薦產品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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其他客户在看

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Zidovudine
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3962-3964 (2017)
Zidovudine
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 45(1), 4630-4630 (2013)
Antiretroviral drugs
Warnke D
Journal of Clinical Pharmacology, 47(12), 1570-1579 (2007)
E Lutsenko et al.
Mutation research, 437(1), 11-20 (1999-07-30)
In Escherichia coli and human cells, many sites of cytosine methylation in DNA are hot spots for C to T mutations. It is generally believed that T.G mismatches created by the hydrolytic deamination of 5-methylcytosines (5meC) are intermediates in the
T R Waters et al.
Mutation research, 462(2-3), 137-147 (2000-04-18)
About 23% of mutations in hereditary human diseases and 24% of mutations in p53 in human cancers are G to A transitions at sites of cytosine methylation suggesting that these sites are either foci for DNA damage, or foci for

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