品質等級
化驗
≥95% (HPLC)
形狀
liquid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
運輸包裝
wet ice
儲存溫度
−20°C
一般說明
一种细胞渗透性苯并噻吩化合物，可通过与Smo七次跨膜螺旋结构域（KD = 59 nM）相互作用，调节Smo与其下游效应器的偶联。显示可诱导刺猬通路激活（NIH 3T3衍生Shh-LIGHT2细胞中的EC50 ∼3 nM）并抵消环巴胺-KAAD（目录号239804）对Smo的抑制。据报道，在低浓度下作为激活剂，在极高浓度下作为抑制剂。
包裝
用惰性气体包装
警告
毒性：标准处理（A）
外觀
10 mM (500 µg/86 µl)Smoothened激动剂溶液，SAG (目录号566660)的H₂O溶液。
重構
初次融化后，等分并冷冻（-20°C）。
其他說明
Meloni, A.R., et al. 2006.Mol.Cell.Biol.26, 7750.
Chen, W., et al. 2004.Science306, 2257.
Chen, J.K., et al. 2002.Proc.Natl.Acad.Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002.J. Biol.1, 10.
Chen, W., et al. 2004.Science306, 2257.
Chen, J.K., et al. 2002.Proc.Natl.Acad.Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002.J. Biol.1, 10.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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