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Merck
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文件

SML1314

Sigma-Aldrich

SAG 二盐酸盐

≥98% (HPLC), lyophilized solid, smoothened (Smo) agonist

别名:

3-氯-N-[反式-4-（甲氨基）环己基]-N- [[3-（4-吡啶）苯基] 甲基]-苯并 [b] 噻吩-2-甲酰胺 二盐酸盐, Smoothened 激动剂

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About This Item

经验公式（希尔记法）:
C28H28ClN3OS · 2HCl
CAS号:
912545-86-9
分子量:
562.98
分類程式碼代碼:
51111800
PubChem物質ID:
329825779
NACRES:
NA.77

product name

SAG 二盐酸盐, ≥98% (HPLC)

品質等級

100

化驗

≥98% (HPLC)

形狀

lyophilized solid

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 20 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

O=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4

InChI

1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-

InChI 密鑰

VFSUUTYAEQOIMW-YHBQERECSA-N

應用

Smoothened激动剂(SAG)二盐酸盐作为音猬因子(sonic hedgehog, SHH)通路激动剂已用于：
  • 研究其对小鼠海马体细胞的影响
  • 研究其对斑马鱼胚胎线粒体网络的影响
  • 研究其对鼠胚胎成纤维细胞的影响

生化／生理作用

SAG 是一种强效且具有细胞渗透性的 smoothened (Smo) 激动剂，可激活 Hedgehog 途径，抵消环巴胺对 Smo 的抑制。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301,H413

危險分類

Acute Tox. 3 Oral - Aquatic Chronic 4

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Michaela Prochazkova et al.
Development (Cambridge, England), 144(12), 2212-2221 (2017-05-17)
The patterning of repeated structures is a major theme in developmental biology, and the inter-relationship between spacing and size of such structures is an unresolved issue. Fungiform papillae are repeated epithelial structures that house taste buds on the anterior tongue.
Suping Qin et al.
Behavioural brain research, 367, 91-100 (2019-04-04)
Obesity induces hippocampal neuronal apoptosis and leads to cognitive function deficits. Sonic hedgehog (SHH) signaling is crucial during nervous system development and is neuroprotective in many neurologic diseases. This study assessed the role of SHH signaling in the cognitive deficits
Friederike Hantel et al.
Journal of cell science, 135(9) (2022-05-12)
Cilia are evolutionarily conserved organelles that orchestrate a variety of signal transduction pathways, such as sonic hedgehog (SHH) signaling, during embryonic development. Our recent studies have shown that loss of GID ubiquitin ligase function results in aberrant AMP-activated protein kinase
Maike Marczenke et al.
Development (Cambridge, England), 148(21) (2021-10-27)
Growth arrest-specific 1 (GAS1) acts as a co-receptor to patched 1, promoting sonic hedgehog (SHH) signaling in the developing nervous system. GAS1 mutations in humans and animal models result in forebrain and craniofacial malformations, defects ascribed to a function for

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