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N-008

Supelco

S(−)-尼古丁 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

别名:

(−)-尼古丁 溶液

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About This Item

经验公式（希尔记法）:
C10H14N2
CAS号:
54-11-5
分子量:
162.23
Beilstein:
5733110
MDL號碼:
MFCD00006369
分類程式碼代碼:
41116107
PubChem物質ID:
329818397
NACRES:
NA.24

等級

certified reference material

形狀

liquid

特點

Snap-N-Spike®/Snap-N-Shoot®

包裝

ampule of 1 mL

製造商／商標名

Cerilliant®

濃度

1.0 mg/mL in methanol

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

forensics and toxicology

格式

single component solution

儲存溫度

−20°C

SMILES 字串

CN1CCC[C@H]1c2cccnc2

InChI

1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1

InChI 密鑰

SNICXCGAKADSCV-JTQLQIEISA-N

基因資訊

human ... CHRNA4(1137) , CHRNB2(1141)

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相关类别

一般說明

Certified Spiking Solution® （认证加标溶液）适用于LC/MS或GC/MS应用，如尼古丁检测、司法鉴定或临床和诊断检验。尼古丁是高度成瘾性烟碱，可能会造成罹患心脏、神经疾病和癌症等无数健康风险。

應用


  • Chiral nicotine for neuroreceptor research: S(−)-Nicotine solution is extensively used in neuroreceptor studies, particularly targeting cholinergic receptors. This enantiopure nicotine variant helps in understanding the binding affinity and activity differences between nicotine isomers, contributing to more targeted neuropharmacological interventions (Lu and Gao, 2024).

  • Pharmacological experiments in addiction research: The optically active form of S(−)-Nicotine is critical for addiction research, where it is used to investigate the pharmacodynamics and addictive properties of nicotine. Studies using this compound help in developing therapeutic strategies for smoking cessation and understanding the biochemical pathways involved in nicotine addiction (Yang et al., 2024).

  • Enantiomer specificity in biochemical studies: High purity S(−)-Nicotine is crucial for assays that require precise control over biochemical properties. Its application in cholinergic receptor assays helps to elucidate the specific interactions and effects of the S(−) enantiomer compared to its R(+) counterpart, thereby enhancing the accuracy of pharmacological models (Mancuso et al., 2024).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes,Central nervous system

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

49.5 °F - closed cup

閃點（°C）

9.7 °C - closed cup

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Manoranjan S D'Souza et al.
Cold Spring Harbor perspectives in medicine, 3(6), doi:10-doi:10 (2013-06-05)
Nicotine plays an important role in the initiation and maintenance of tobacco smoking. Importantly, chronic nicotine exposure alters the function of brain reward systems, resulting in the development of a nicotine-dependent state. This nicotine-dependent state is associated with aversive affective
Christie D Fowler et al.
Neuropharmacology, 76 Pt B, 533-544 (2013-09-24)
Nicotine stimulates brain reward circuitries, most prominently the mesocorticolimbic dopamine system, and this action plays a critical in establishing and maintaining the tobacco smoking habit. Compounds that attenuate nicotine reward are considered promising therapeutic candidates for tobacco dependence, but many
Marina R Picciotto et al.
Neuropharmacology, 76 Pt B, 545-553 (2013-05-02)
Tobacco smoking in humans is one of the most persistent and widespread addictions and is driven by nicotine in tobacco smoke. Over the last several decades, understanding of the molecular and cellular basis for nicotine addiction has increased tremendously as
Lindsay F Stead et al.
The Cochrane database of systematic reviews, 11, CD000146-CD000146 (2012-11-16)
The aim of nicotine replacement therapy (NRT) is to temporarily replace much of the nicotine from cigarettes to reduce motivation to smoke and nicotine withdrawal symptoms, thus easing the transition from cigarette smoking to complete abstinence. The aims of this
Neal L Benowitz et al.
Tobacco control, 22 Suppl 1, i14-i17 (2013-04-23)
Nicotine is highly addictive and is primarily responsible for the maintenance of cigarette smoking. In 1994, Benowitz and Henningfield proposed the idea of federal regulation of the nicotine content of cigarettes such that the nicotine content of cigarettes would be
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商品

LC/MS Analysis of Nicotine and Metabolites on Kromasil® Eternity™ C18 (Analyte Set 1)

Separation of (+)-Anabasine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material; S(−)-Nicotine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material; (S)-N-Nitrosoanabasine (NAB) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material

LC/MS Analysis of Nicotine and Metabolites on Kromasil® Eternity™ C18 (Analyte Set 1)

Separation of (+)-Anabasine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material; S(−)-Nicotine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material; (S)-N-Nitrosoanabasine (NAB) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material

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