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Merck

E18425

Sigma-Aldrich

氰乙酸乙酯

≥98%

别名:

α-氰基乙酸乙酯, 2-氰基乙酸乙酯, 3-乙氧基-3-氧代丙腈, 丙二酸乙酯腈, 氰基乙酸乙酯, 氰基乙酸酯, (乙氧基碳基)乙腈

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About This Item

线性分子式:
NCCH2COOC2H5
CAS号:
分子量:
113.11
Beilstein:
605871
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

蒸汽密度

3.9 (vs air)

品質等級

蒸汽壓力

1 mmHg ( 67.8 °C)

化驗

≥98%

形狀

liquid

折射率

n20/D 1.418 (lit.)

bp

208-210 °C (lit.)

mp

−22 °C (lit.)

密度

1.063 g/mL at 25 °C (lit.)

SMILES 字串

CCOC(=O)CC#N

InChI

1S/C5H7NO2/c1-2-8-5(7)3-4-6/h2-3H2,1H3

InChI 密鑰

ZIUSEGSNTOUIPT-UHFFFAOYSA-N

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一般說明

氰基乙酸乙酯是酯。报道了氰基乙酸乙酯与醛的Knoevenagel 缩合反应。研究人员报道了氰基乙酸乙酯与醛、P2O5、哌啶和氯苯的微波增强Knoevenegal 缩合反应。

氰基乙酸乙酯广泛用作有机合成中的合成砌块,用于生成活性药物成分。

應用

氰基乙酸乙酯可用于合成乙醛酸乙酯。通过将氨基嫁接到 NaX和CsNaX 沸石上获得的沸石催化剂,并将其用于研究微反应器中的Knoevenagel 缩合反应。

包裝

封装在玻璃瓶中

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

230.0 °F

閃點(°C)

110 °C

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Korany A Ali et al.
Mini reviews in medicinal chemistry, 18(8), 717-727 (2017-04-27)
In this study, synthesis, molecular docking and anticancer screening of new series of substituted heterocycles with trimethoxy phenyl scaffold as Combretastatin analogues were described. Substituted pyridines were synthesized via the reaction of (E)-3-(dimethylamino)-1-(3,4,5- trimethoxyphenyl)prop-2-en-1-one (2) with active methylene reagents. Substituted
Mohie E M Zayed et al.
Journal of fluorescence, 27(3), 853-860 (2017-01-23)
4-(2,3,4-trimethoxyphenyl)-8-methoxy-2-oxo-1,2,5,6 tetrahydrobenzo [h] quinoline-3-carbonitrile (TMTQ) dye was synthesized by one-pot multicomponent reactions (MCRs) of 2,3,4 trimethoxybenzaldehyd, ethyl cyanoacetate, 6-methoxy-1,2,3,4-tetrahydro-naphthalin-1-one and ammonium acetate under microwave irradiation. The structures of the synthesized compound was established by spectroscopic (FT-IR
Electrogenerated bases VII. Novel syntheses of ethyl glyoxalate and diethyl ketomalonate via electrogenerated superoxide.
Sugawara M and Baizer MM.
Tetrahedron Letters, 24(22), 2223-2226 (1983)
Microwave Enhanced Knoevenagel Condensation of Ethyl Cyanoacetate with Aldehydes.
Kim S-Y, et al.
Synthetic Communications, 27(4), 533-541 (1997)
The Knoevenagel condensation of aromatic aldehydes with malononitrile or ethyl cyanoacetate in the presence of CTMAB in water.
Wang S, et al.
Synthetic Communications, 31(5), 673-677 (2001)

商品

Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.

Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.

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