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482609

Sigma-Aldrich

N-[(2S,3R)-3-氨基-2-羟基-4-苯基丁酰基]-L-亮氨酸

97%

别名:

([2S,3R]-3-氨基-2-羟基-4-苯基丁酰基)-L-亮氨酸

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About This Item

线性分子式:
(CH3)2CHCH2CH[NHCOCH(OH)CH(NH2)CH2C6H5]CO2H
CAS号:
58970-76-6
分子量:
308.37
EC號碼:
261-529-2
MDL號碼:
MFCD00083262
分類程式碼代碼:
12352209
PubChem物質ID:
24871835
NACRES:
NA.22

品質等級

100

化驗

97%

形狀

powder or crystals

光學活性

[α]20/D −11°, c = 1 in 1 M NaOH

反應適用性

reaction type: solution phase peptide synthesis

mp

245 °C (dec.) (lit.)

應用

peptide synthesis

SMILES 字串

CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O

InChI

1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1

InChI 密鑰

VGGGPCQERPFHOB-RDBSUJKOSA-N

基因資訊

human ... ANPEP(290) , DPP4(1803)
mouse ... Rnpep(215615)
rat ... Mme(24590)

相关类别

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCD4914
MKBW9442V
MKBR2220V
MKBK0650V
MKBJ8307V

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Arun Kumar Singh et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 16(5), e375-e381 (2012-03-14)
Staphylococcus aureus has emerged as a major drug-resistant pathogen in hospital- and community-acquired infections. Leucine aminopeptidase (LAP) is known to be essential for survival of the bacteria; however the LAP of S. aureus has not been extensively characterized. In this
Jung-Mi Kang et al.
Molecular and biochemical parasitology, 182(1-2), 17-26 (2011-12-14)
Leucine aminopeptidases (LAP; EC 3.4.11.1) are a group of metalloexopeptidases, which catalyze the sequential removal of leucine amino acids from the N-termini of the polypeptides or proteins. In this study, we identified two novel genes that encode LAPs of Clonorchis
Xiaopan Zhang et al.
Journal of enzyme inhibition and medicinal chemistry, 28(3), 545-551 (2012-03-03)
Aminopeptidase N (APN/CD13) over expressed on tumour cells, plays a critical role in tumour invasion, metastasis and tumour angiogenesis. In this article, we described the design, synthesis and preliminary activity studies of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as APN inhibitors. The
Daniela P Alves et al.
Pharmacology, 89(1-2), 22-28 (2012-01-13)
The aim of the present study was to investigate the mechanisms underlying the endogenous control of nociception at a peripheral level during inflammation. Using a pharmacological approach and the rat paw pressure test, we assessed the effect of an intraplantar
M Lis et al.
Polish journal of veterinary sciences, 14(3), 393-403 (2011-10-01)
Bestatin, a low-molecular weight dipeptide, is a potent inhibitor of aminopeptidase N which has been demonstrated to have antitumor and immunomodulatory effects. The effects of bestatin (10, 1 and 0.1 mg/kg) administered intraperitoneally once, five or ten times to mice
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Global Trade Item Number

货号GTIN
482609-500MG4061832594989

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