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About This Item
经验公式（希尔记法）:
C16H24N2O4 · HCl
CAS号:
分子量:
344.83
Beilstein:
4628066
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77
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产品名称
苯丁抑制素 盐酸盐, ≥98% (HPLC)
生物源
synthetic (organic)
化驗
≥98% (HPLC)
形狀
powder
mp
216 °C
溶解度
water: 25 mg/mL, clear to very slightly hazy, colorless
抗生素活性譜
neoplastics
作用方式
enzyme | inhibits
儲存溫度
−20°C
SMILES 字串
O=C(N[C@@H](CC(C)C)C(O)=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1.Cl[H]
InChI
1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
InChI 密鑰
XGDFITZJGKUSDK-UDYGKFQRSA-N
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一般說明
化学结构：氨基酸衍生物
生化／生理作用
一种氨肽酶选择性金属蛋白酶抑制剂。苯丁抑制素是亮氨酸氨基肽酶、氨基肽酶 B 和三氨基肽酶的竞争性和特异性抑制剂。在 60 nM 抑制氨肽酶 B（用精氨酸-β-萘胺为底物）和亮氨酸氨基肽酶在 20 nM（亮氨酸-β-萘胺为底物）。其显示对氨肽酶 A、胰蛋白酶、糜蛋白酶、弹性蛋白酶、木瓜蛋白酶、胃蛋白酶或溶血素无抑制作用。它有希望成为一种新型镇痛药，因为它能保护内源性阿片肽免受降解。
準備報告
在 25 mg/mL 水中进行溶解度试验，得到澄清溶液。预期 1 mM 储备液至少稳定 20°C 条件下储存 1 个月。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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