Z3777

ZD7288 hydrate

≥98% (HPLC)

• Sinonimo/i: 4-(N-Ethyl-N-phenylamino)-1,2 dimethyl-6-(methylamino) pyrimidinium chloride, ICI-D7288, N-Ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine hydrochloride, ZD 7288
• Formula empirica (notazione di Hill): C₁₅H₂₀N₄ · HCl · xH₂O
• Peso molecolare: 292.81 (anhydrous basis)
• Numero MDL: MFCD16879001
• Codice UNSPSC: 12352200
• ID PubChem: 329831610
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to beige
• Solubilità: DMSO: 10 mg/mL, clear
• Ideatore: AstraZeneca
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O.Cl.CCN(c1ccccc1)C2=CC(=N/C)\N(C)C(C)=N2
• InChI: 1S/C15H20N4.ClH.H2O/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;;/h6-11H,5H2,1-4H3;1H;1H2/b16-14+;;; NCEDDDWQLCMZQG-UPONXUSQSA-N

Descrizione

Applicazioni

ZD7288 hydrate has been used as I_h blocker to study its effect on
neocortical tissue. It has been used as hyperpolarization-activated and cyclic nucleotide-gated (HCN)-channel blocker to test the involvement of HCN channels in the phototransduction pathway.

Azioni biochim/fisiol

Selective blocker of cation channel Ih; If blocker and sino-atrial node function modulator, blocks hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels.

ZD7288 can block hippocampal synaptic plasticity.

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable