Z0127

Zatebradine hydrochloride

≥98% (HPLC), powder

• Sinonimo/i: 7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride, UL-FS49
• Formula empirica (notazione di Hill): C₂₆H₃₇ClN₂O₅
• Numero CAS: 91940-87-3
• Peso molecolare: 493.04
• Numero MDL: MFCD06798356
• Codice UNSPSC: 12352200
• ID PubChem: 24724672
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white
• Solubilità: H₂O: >10 mg/mL
• Ideatore: Boehringer Ingelheim
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Cl[H].COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
• InChI: 1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H; ZRNKXJHEQKMWCH-UHFFFAOYSA-N

Descrizione

Applicazioni

Zatebradine hydrochloride has been used:

• as an I_f blocker to study its effects on cardiomyocyte clusters (CMCs)
• as a hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel inhibitor to study its effects on viability of degenerating rod or cone photoreceptors in mice
• as a bradycardiac agent to study its effects on tachycardia and elevated temperature in fish

Azioni biochim/fisiol

HCN channel blocker: blocker of neuronal I_h, related cardiac I_f channels and ATP-sensitive K_ir channels.

Zatebradine is a bradycardiac agent.

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)