T3757

TTNPB

• Sinonimo/i: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid, Arotinoid acid
• Formula empirica (notazione di Hill): C₂₄H₂₈O₂
• Numero CAS: 71441-28-6
• Peso molecolare: 348.48
• Numero MDL: MFCD00673917
• Codice UNSPSC: 12352200
• ID PubChem: 24278733
• NACRES: NA.77

Proprietà

• Solubilità: ethanol: soluble 10 mM; DMSO: soluble 25 mM; chloroform/methanol: soluble 9.80-10.20 mg/mL, clear, colorless to light yellow
• Livello qualitativo: 200
• Temperatura di conservazione: −20°C
• Stringa SMILE: C\C(=C/c1ccc(cc1)C(O)=O)c2ccc3c(c2)C(C)(C)CCC3(C)C
• InChI: 1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+; FOIVPCKZDPCJJY-JQIJEIRASA-N
• Informazioni sul gene: human ... RARA(5914) , RARB(5915) , RARG(5916) , RXRA(6256) , RXRB(6257) , RXRG(6258)

Descrizione

Applicazioni

TTNPB has been used for transcriptional assays in 293T cells⁴. It has also been used as a RAR-agonist in cultured human cord blood CD34⁺CD38^-lin^- cells⁵.

Azioni biochim/fisiol

Selective and highly potent retinoic acid analog with affinity for retinoic acid receptors (RAR) α, β, and γ, which are nuclear transcription factors. Produces ligand-activated transcription of genes that possess retinoic acid responsive elements.

Caratteristiche e vantaggi

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota sulla preparazione

TTNPB dissolves in CHCL3/MeOH (1/1) at 9.80 - 10.20 mg/ml to yield a clear, colorless to light yellow solution. It is also soluble at 10 mM in ethanol and at 25 mM in DMSO.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H315,H319,H335,H360
• Consigli di prudenza: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges