G5172

GW4064

≥97% (HPLC)

• Sinonimo/i: 3-(2,6-Dichlorophenyl)-4-(3’-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole
• Formula empirica (notazione di Hill): C₂₈H₂₂Cl₃NO₄
• Numero CAS: 278779-30-9
• Peso molecolare: 542.84
• Numero MDL: MFCD09971006
• Codice UNSPSC: 12352200
• ID PubChem: 329799937
• NACRES: NA.32

Proprietà

• Livello qualitativo: 100
• Saggio: ≥97% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white
• Solubilità: DMSO: 10 mg/mL, clear
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CC(C)c1onc(c1COc2ccc(\C=C\c3cccc(c3)C(O)=O)c(Cl)c2)-c4c(Cl)cccc4Cl
• InChI: 1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+; BYTNEISLBIENSA-MDZDMXLPSA-N

Descrizione

Descrizione generale

GW4064 is a synthetic isoxazole, which is used to decipher the cellular and physiological functions of farnesoid X receptor (FXR). It is an estrogen receptor-related receptors (ERRs) agonist.

Applicazioni

GW4064 has been used:

• to investigate its ability to protect the livers of mice from lipopolysaccharide (LPS)-induced inflammation and apoptosis
• to examine its capability to inhibit mucosal injury in ileum caused by lipopolysaccharide (LPS)
• to treat ileal explants

Azioni biochim/fisiol

GW4064 is a FXR agonist. GW4064 is a potent (EC50 = 15 nM), non-steroidal agonist of the orphan nuclear receptor FXR. It shows no activity on other nuclear receptors including RAR up to 1 mM. This is an important tool for the study of the involvment of FXR in a variety of biological activities.

Caratteristiche e vantaggi

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H319,H413
• Consigli di prudenza: P273 - P301 + P312 + P330 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves