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Merck
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Documenti fondamentali

SRP8047

Sigma-Aldrich

Omentin human

recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)

Sinonimo/i:

ACRP30headless:TNFSF13, Endothelial lectin HL-1, Galactofuranose-binding Lectin, Intestinal lactoferrin receptor, Omentin 1

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About This Item

Numero CAS:
786735-12-4
Codice UNSPSC:
12352200
NACRES:
NA.32

Origine biologica

human

Ricombinante

expressed in CHO cells

Tag

FLAG® tagged

Saggio

>95% (SDS-PAGE)

Stato

lyophilized

PM

~38 kDa

Confezionamento

pkg of 10 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

tecniche

ligand binding assay: suitable

Impurezze

<0.1 EU/μg endotoxin, tested

Colore

white

N° accesso UniProt

Q8WWA0

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... ITLN1(55600)

Descrizione generale

Omentin (intelectin-1) is highly expressed in omental adipose tissue, small intestine and various other tissues. It is a plasma adipokine made up of 313 amino acids.

Applicazioni

Omentin (intelectin-1) has been used in intelectin binding and cleavage assays.

Azioni biochim/fisiol

Omentin (intelectin-1) has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. It increases protein kinase B (AKT) phosphorylation in the absence and presence of insulin. Omentin was suggested to play a role in the defense system against microorganisms by recognizing carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues. It has anti-inflammatory and insulin-sensitizing properties. The protein may be a biomarker of metabolic disorders. It has been shown to be over-expressed in human malignant pleural mesothelioma (MPM).

Stato fisico

Lyophilized from PBS.

Ricostituzione

Reconstitute with 100 μL deionized water.

Altre note

Human omentin (aa 17-313) is fused at the N-terminus to a FLAG®-tag.

Note legali

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
P20351002

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Michael Sigal et al.
Nature cell biology, 21(7), 812-823 (2019-06-27)
Wnt signalling stimulated by binding of R-spondin (Rspo) to Lgr-family members is crucial for gastrointestinal stem cell renewal. Infection of the stomach with Helicobacter pylori stimulates increased secretion of Rspo by myofibroblasts, leading to an increase in proliferation of Wnt-responsive
Chemoproteomic profiling of host and pathogen enzymes active in cholera.
Hatzios SK
Nature Chemical Biology, 12(4), 268-274 (2016)
Dan Li et al.
Oncotarget, 6(18), 16168-16182 (2015-05-13)
Recent evidence shows the emerging roles of intelectin 1 (ITLN1), a secretory lectin, in human cancers. Our previous studies have implicated the potential roles of ITLN1 in the aggressiveness of gastric cancer. Herein, we investigated the functions, downstream targets, and
Circulating levels of adipocytokine omentin-1 in patients with renal cell cancer.
Shen XD
Cytokine, 77, 50-55 (2016)
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.
Yang RZ
American Journal of Physiology. Endocrinology and Metabolism, 290(6), E1253-E1261 (2006)
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