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S5567

Sigma-Aldrich

SP600125

≥98% (HPLC), powder or solid, JNK inhibitor

Sinonimo/i:

1,9-Pyrazoloanthrone, Anthrapyrazolone

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About This Item

Formula empirica (notazione di Hill):
C14H8N2O
Numero CAS:
129-56-6
Peso molecolare:
220.23
Numero CE:
204-955-6
Numero MDL:
MFCD00022289
Codice UNSPSC:
12352200
ID PubChem:
24278395
NACRES:
NA.77

Nome del prodotto

SP600125, ≥98% (HPLC)

Saggio

≥98% (HPLC)

Colore

yellow

Solubilità

DMSO: 20 mg/ml, clear to very slightly hazy, faintly yellow to yellow
H2O: insoluble

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C1c2ccccc2-c3n[nH]c4cccc1c34

InChI

1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
ACPOUJIDANTYHO-UHFFFAOYSA-N

Informazioni sul gene

human ... JUN(3725) , MAPK10(5602) , MAPK9(5601)

Applicazioni

C2C12 myoblasts were treated with SP600125 to test the stimulation of myogenesis.11 It was used to treat HepG2 cells to test the effects on oxysterol-induced necrosis.12

Azioni biochim/fisiol

A novel and selective inhibitor of c-Jun N-terminal kinase (JNK)
SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.10

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
SLCL0779
SLCF3483
SLBZ2821
SLBV9772
SLBQ9854V

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SB 203580 SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).

Sigma-Aldrich

559389

SB 203580

U0126 U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.

Sigma-Aldrich

19-147

U0126

JNK Inhibitor V The JNK Inhibitor V, also referenced under CAS 345987-15-7, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

420129

JNK Inhibitor V

JNK Inhibitor I, (L)-Form, Cell-Permeable The JNK Inhibitor I, (L)-Form, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

420116

JNK Inhibitor I, (L)-Form, Cell-Permeable

Bay 11-7082 ≥98% (HPLC), powder

Sigma-Aldrich

B5556

Bay 11-7082

PD 98059

Sigma-Aldrich

19-143

PD 98059

PD153035 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0564

PD153035 hydrochloride

BMS-345541 ≥98% (HPLC), powder

Sigma-Aldrich

B9935

BMS-345541

JNK Inhibitor VIII The JNK Inhibitor VIII, also referenced under CAS 894804-07-0, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

420135

JNK Inhibitor VIII

Chenglu Peng et al.
Journal of agricultural and food chemistry, 67(32), 9009-9021 (2019-07-19)
Soybean allergy is a serious health risk to humans and animals; β-conglycinin is the primary antigenic protein in soybean. Intestinal porcine epithelial (IPEC-J2) cells were used as an in vitro physiological model of the intestinal epithelium to study the effects
Cheng Yin et al.
Cell transplantation, 28(6), 691-703 (2018-10-24)
Following central nervous system injury in mammals, failed axonal regeneration is closely related to dysneuria. Previous studies have shown that the obvious effects of apolipoprotein E (ApoE) on traumatic brain injury (TBI) were associated with an axonal mechanism. However, little
Donia Mili et al.
Molecular cytogenetics, 9, 86-86 (2016-12-08)
The JNK inhibitor SP600125 strongly inhibits cell proliferation in many human cancer cells by blocking mitosis progression and inducing cell death. Despite, all this study, the mechanism by which SP600125 inhibits mitosis-related effects in human cervical cells (HeLa cells) remains
Adrian Vallejo et al.
Nature communications, 8, 14294-14294 (2017-02-22)
KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative therapeutic strategies. Here we report
Wen Yuan Luo et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 16(3), 761-783 (2019-05-11)
Targeting mGluR5 has been an attractive strategy to modulate glutamate excitotoxicity for neuroprotection. Although human clinical trials using mGluR5 negative allosteric modulators (NAMs) have included some disappointments, recent investigations have added several more attractive small molecules to this field, providing
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