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Key Documents

19-147

Sigma-Aldrich

U0126

solid, suitable for kinase activity assay

Sinonimo/i:

Kinase inhibitor, MEK inhibitor

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About This Item

Codice UNSPSC:
12352200
eCl@ss:
32160405
NACRES:
NA.41

product name

U0126, U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.

Livello qualitativo

100

Forma fisica

solid

Produttore/marchio commerciale

Upstate®

tecniche

activity assay: suitable (kinase)

N° accesso NCBI

NM_002755.2

N° accesso UniProt

P36507
Q02750

Condizioni di spedizione

wet ice

Informazioni sul gene

human ... MAP2K1(5604)

Azioni biochim/fisiol

Inhibitor Type: Kinase
Protein Target: MAPKK 1

Stato fisico

C18H16N6S2

Stoccaggio e stabilità

2 years at -20°C

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Sigma-Aldrich

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Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes.
Scherle, P A, et al.
Journal of immunology (Baltimore, Md. : 1950), 161, 5681-5686 (1998)
Jahangir Iqbal et al.
The Journal of biological chemistry, 295(13), 4101-4113 (2020-02-13)
The hormone leptin regulates fat storage and metabolism by signaling through the brain and peripheral tissues. Lipids delivered to peripheral tissues originate mostly from the intestine and liver via synthesis and secretion of apolipoprotein B (apoB)-containing lipoproteins. An intracellular chaperone
D R DeSilva et al.
Journal of immunology (Baltimore, Md. : 1950), 160(9), 4175-4181 (1998-05-09)
Three mitogen-activated protein kinase pathways are up-regulated during the activation of T lymphocytes, the extracellular signal-regulated kinase (ERK), Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase pathways. To examine the effects of blocking the ERK pathway on T cell activation
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mBio, 11(6) (2020-11-12)
Inflammation triggered by innate immunity promotes carcinogenesis in cancer. Kaposi's sarcoma (KS), a hyperproliferative and inflammatory tumor caused by Kaposi's sarcoma-associated herpesvirus (KSHV) infection, is the most common cancer in AIDS patients. KSHV infection sensitizes cells to pathogen-associated molecular patterns
M F Favata et al.
The Journal of biological chemistry, 273(29), 18623-18632 (1998-07-11)
The compound U0126 (1,4-diamino-2,3-dicyano-1, 4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1 transactivation in a cell-based reporter assay. U0126 was also shown to inhibit endogenous promoters containing AP-1 response elements but did not affect genes lacking an AP-1 response element
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