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Merck
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Key Documents

19-142

Sigma-Aldrich

LY 294002

Sinonimo/i:

NSC 697286, PI3K inhibitor, SF 1101

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About This Item

Codice UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.41

Forma fisica

solid

Livello qualitativo

Produttore/marchio commerciale

Upstate®

tecniche

activity assay: suitable (kinase)

Condizioni di spedizione

wet ice

Applicazioni

Specific and potent inhibitor of PI 3-kinase.

Azioni biochim/fisiol

Inhibitor Type: Kinase

Stato fisico

C19H17NO3

Stoccaggio e stabilità

2 years at -20°C

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

487.4 °F

Punto d’infiammabilità (°C)

253.0 °C


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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SB 203580 solid, ≥98% (HPLC)

Sigma-Aldrich

S8307

SB 203580

PD 98,059 solid

Sigma-Aldrich

P215

PD 98,059

Sigma-Aldrich

Sigma-Aldrich

SML0749

SC79

U0126 U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.

Sigma-Aldrich

19-147

U0126

U0126 U0126, CAS 109511-58-2, is a potent and specific inhibitor of MEK1 (IC₅₀ = 72 nM) and MEK2 (IC₅₀ = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK.

Sigma-Aldrich

662005

U0126

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C J Vlahos et al.
The Journal of biological chemistry, 269(7), 5241-5248 (1994-02-18)
Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor and nonreceptor tyrosine kinases, including the platelet-derived growth factor receptor. Inhibitors of PtdIns 3-kinase could potentially give a better understanding of the function and
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The American journal of pathology, 191(3), 515-526 (2020-12-22)
Nerve infiltration into the tumor is a common feature of the tumor microenvironment. The mechanisms of axonogenesis in breast cancer remain unclear. We hypothesized that vascular endothelial growth factor (VEGF), as well as nerve growth factor (NGF), is involved in
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The Journal of biological chemistry, 278(33), 30821-30827 (2003-06-12)
Endothelial nitric-oxide synthase (eNOS), which generates the endogenous vasodilator, nitric oxide (NO), is highly regulated by post-translational modifications and protein interactions. We recently used purified proteins to characterize the mechanisms by which heat shock protein 90 (HSP90) increases eNOS activity
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Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group of natural antimicrobial peptides, have antimicrobial and immunomodulatory activities in Clostridioides difficile infection. Here, we have shown that cytokine IL-27

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

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