SML3362

YM-244769 dihydrochloride

≥98% (HPLC)

• Sinonimo/i: N-​[(3-​Aminophenyl)​methyl]​-​6-​[4-​[(3-​fluorophenyl)​methoxy]​phenoxy]​-3-​pyridinecarboxamide dihydrochloride, N-(3-Aminobenzyl)-6-{4-[3-fluorobenzyl)oxy]phenoxy} nicotinamide dihydrochloride
• Formula empirica (notazione di Hill): C₂₆H₂₂FN₃O₃·2HCl
• Numero CAS: 1780390-65-9
• Peso molecolare: 516.39
• Numero MDL: MFCD28160863
• Codice UNSPSC: 51111800
• Codice UNSPSC: 12352200
• NACRES: NA.21

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to pink
• Solubilità: DMSO: 2 mg/mL, clear
• Temperatura di conservazione: -10 to -25°C
• Stringa SMILE: O=C(C1=CC=C(OC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)N=C1)NCC4=CC=CC(N)=C4
• InChI: 1S/C26H22FN3O3/c27-21-5-1-4-19(13-21)17-32-23-8-10-24(11-9-23)33-25-12-7-20(16-29-25)26(31)30-15-18-3-2-6-22(28)14-18/h1-14,16H,15,17,28H2,(H,30,31); JZMLHJRKSJXARY-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Potent and selective inhibitor of Na+/Ca2+ exchange (NCX) acting preferentially at NCX3

YM-244769 hydrochloride is a potent and selective inhibitor of Na+/Ca2+ exchange (NCX) acting preferentially at NCX3. It inhibits the Ca2+ entry mode of NCX more potently than the Ca2+ exit mode. YM-244769 exhibits protection in various hypoxic/ischemic cell injury models with low cell toxicity.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable