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P4553

Sigma-Aldrich

6-Phosphogluconic Dehydrogenase from yeast

lyophilized powder, ≥3.0 units/mg solid

Sinonimo/i:

6-Phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating), 6-Phosphogluconic Dehydrogenase from yeast

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About This Item

Numero CAS:
9073-95-4
Classificazione EC (Enzyme Commission):
1.1.1.44 (BRENDA, IUBMB)
Numero MDL:
MFCD00130317
Codice UNSPSC:
12352204
NACRES:
NA.54

Origine biologica

yeast

Forma fisica

lyophilized powder

Attività specifica

≥3.0 units/mg solid

PM

52 kDa

Temperatura di conservazione

2-8°C

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Descrizione generale

6-Phosphogluconic Dehydrogenase from yeast comprises of a NADP+ binding domain, α helical hydrophobic interaction domain and a C-terminal domain. It exists as dimer and the C-terminal region is crucial for the substrate binding and release.

Applicazioni

6-Phosphogluconic Dehydrogenase from yeast has been used in hexokinase (HK) and xylose reductase (XR) activities in cell lysate.

Azioni biochim/fisiol

Enzyme activity is determined by measuring the reduction of NAD+ or NADP+. High levels of NADPH are believed to inhibit the enzyme, while 6-phosphogluconate acts to activate the enzyme.

Definizione di unità

One unit will oxidize 1.0 μmole of 6-phospho-D-gluconate to D-ribulose 5-phosphate and CO2 per min at pH 7.4 at 37 °C in the presence of NADP+.

Inibitore

N° Catalogo
Descrizione
Determinazione del prezzo

I1149

Iodoacetamide, BioUltra

I6125

Iodoacetamide, ≥99% (NMR), crystalline

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H334

Consigli di prudenza

P261 - P284 - P501

Classi di pericolo

Resp. Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Enhancement of xylose uptake in 2-deoxyglucose tolerant mutant of Saccharomyces cerevisiae
Kahar P, et al.
Journal of Bioscience and Bioengineering, 111(5), 557-563 (2011)
Ai-Hua Jin et al.
BMC structural biology, 7, 28-28 (2007-04-21)
Alpha-conotoxins have exciting therapeutic potential based on their high selectivity and affinity for nicotinic acetylcholine receptors. The spacing between the cysteine residues in alpha-conotoxins is variable, leading to the classification of sub-families. BuIA is the only alpha-conotoxin containing a 4/4
Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1
He W, et al.
BMC Structural Biology, 7(1), 38-38 (2007)
G Martínez-Drets et al.
Journal of bacteriology, 130(3), 1139-1143 (1977-06-01)
6-Phospho-D-gluconate:NAD+ 2-oxidoreductase (decarboxylating) (NAD+-6PGD) was detected in several slow-growing strains of rhizobia, and no activity involving NADP+ was found in the same extracts. By contrast, fast-growing strains of rhizobia had NADP+-6PGD activity; most of them also had NAD+-6PGD activity. NAD+-6PGD
M Zelewski et al.
Biochemistry international, 19(5), 1057-1065 (1989-11-01)
The effect of starvation-refeeding transitions on the activity of malic enzyme and hexosemonophosphate shunt dehydrogenases in lipogenic and non-lipogenic tissues from rats was investigated. Starvation of the rats caused a decrease of malic enzyme activity in the liver, white and
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