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MAK015

Sigma-Aldrich

Glucose-6-Phosphate Dehydrogenase Activity Assay Kit

sufficient for 100 colorimetric tests

Sinonimo/i:

G-6-PD Activity Assay Kit

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About This Item

Codice UNSPSC:
12161503
NACRES:
NA.84

impiego

sufficient for 100 colorimetric tests

Metodo di rivelazione

colorimetric

Malattie correlate

cancer; hematological disorder

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... H6PD(9563)
mouse ... H6PD(100198)
rat ... H6PD(298655)

Descrizione generale

Glucose-6-phosphate dehydrogenase (G6PDH) catalyzes the conversion of glucose-6-phosphate to 6-phosphoglucono-δ-lactone, the first and rate-limiting step of the pentose phosphate pathway (PPP). The PPP pathway critical for maintaining the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH) and for the production of pentose sugars. The NADPH produced is critical for redox regulation via the regeneration of GSH and for providing reducing equivalents for fatty acid biosynthesis. Deficiencies in G6PDH predisposes individuals to non-immune hemolytic anemia.

Applicazioni

Glucose-6-phosphate dehydrogenase assay kit has been used in the determination of glucose-6-phosphate dehydrogenase (G6PDH) activity and to measure PDH (pyruvate dehydrogenase).

Compatibilità

Suitable for the measurement of Glucose-6-phosphate dehydrogenase (G6PDH) activity in various tissues and cells.

Principio

In the glucose-6-phosphate dehydrogenase assay kit, glucose-6-phosphate is oxidized to generate a product which is specifically detected by colorimetric (450 nm) assay. The G6PDH Assay Kit can detect G6PDH activity as low as 0.04mU G6PDH per well.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

06693

Timestrip Plus™ -20 °C

Pittogrammi

Corrosion
GHS05

Avvertenze

Danger

Indicazioni di pericolo

H314

Classi di pericolo

Eye Dam. 1 - Skin Corr. 1B

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

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Nuclear Heme Oxygenase-1 (HO-1) Modulates Subcellular Distribution and Activation of Nrf2, Impacting Metabolic and Anti-oxidant Defenses.
Chhanda B, et al.
The Journal of Biological Chemistry, jbc-M114 (2014)
Redox Regulation of Cell Survival.
Dunyaporn T, et al.
Antioxidants & Redox Signaling, 10(8), 1343-1374 (2008)
Signaling Transduction and Metabolomics
Ronald H, et al.
Hematology (2018)
Living with Glucose-6-Phosphate Dehydrogenase Deficiency
Devi A S, et al.
Journal of nursing science and practice., 6(1) (2016)
Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development
Ying L, et al.
Cell Reports, 14(12), 2889-2900 (2016)
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Articoli

Nucleotide Synthesis in Cancer Cells

Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA.

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