Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

View All Documentation

M0443

Sigma-Aldrich

Mirtazapine

≥98% (HPLC)

Sinonimo/i:

1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C17H19N3
Numero CAS:
85650-52-8
Peso molecolare:
265.35
Numero MDL:
MFCD00865427
Codice UNSPSC:
12352200
ID PubChem:
24724531
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white

Solubilità

DMSO: 8 mg/mL, clear

Stringa SMILE

CN1CCN2C(C1)c3ccccc3Cc4cccnc24

InChI

1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
RONZAEMNMFQXRA-UHFFFAOYSA-N

Informazioni sul gene

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , DRD2(1813) , DRD3(1814) , DRD4(1815) , HRH1(3269) , HTR1A(3350) , HTR2A(3356) , HTR2C(3358) , HTR7(3363)
mouse ... Slc6a2(20538)
rat ... Adra1a(29412) , Drd1a(24316) , Drd2(24318) , Htr1a(24473) , Htr2a(29595) , Htr2c(25187) , Slc6a3(24898) , Slc6a4(25553)

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Azioni biochim/fisiol

Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA). Mirtazapine agonizes selective adrenergic and serotonergic receptors so that both NE release and 5-HT1A mediated serotonergic signaling are increased.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H336

Classi di pericolo

Acute Tox. 4 Oral - STOT SE 3

Organi bersaglio

Central nervous system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

M A Raji et al.
The Annals of pharmacotherapy, 35(9), 1024-1027 (2001-09-28)
Depression in patients with Alzheimer disease is a treatable cause of functional decline, caregiver burden, and mortality. It is often associated with severe weight loss, insomnia, and anxiety. These symptoms independently and collaboratively further worsen the prognosis of these vulnerable
S A Anttila et al.
CNS drug reviews, 7(3), 249-264 (2001-10-19)
The novel antidepressant mirtazapine has a dual mode of action. It is a noradrenergic and specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic alpha2-autoreceptors and alpha2-heteroreceptors as well as by blocking 5-HT2 and 5-HT3 receptors. It enhances, therefore
B Milne et al.
British journal of pharmacology, 155(8), 1264-1278 (2008-09-23)
Ultra-low doses of opioid receptor antagonists augment spinal morphine antinociception and block the induction of tolerance. Considering the evidence demonstrating functional and physical interactions between the opioid and alpha(2)-adrenoceptors, this study investigated whether ultra-low doses of alpha(2)-adrenoceptor antagonists also influence
David E Kemp
Journal of affective disorders, 169 Suppl 1, S34-S44 (2014-12-24)
The most commonly used pharmacologic therapies for bipolar depression are mood stabilizers, atypical antipsychotics, and antidepressants. This paper reviews common side effects associated with these medications and provides recommendations for managing adverse medication effects in clinical practice. Narrative review based
Hun Soo Chang et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(1), 59-68 (2014-12-03)
Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis is among the most consistent neuroendocrine abnormalities in major depressive disorder (MDD). The peptide adrenocorticotropin hormone (ACTH) mediates HPA axis function during stress and is encoded by the proopiomelanocortin (POMC) gene polycistronically. After screening
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.