G5884

Guanosine 5′-triphosphate lithium salt

~95% (HPLC), powder

• Sinonimo/i: GTP lithium salt
• Formula empirica (notazione di Hill): C₁₀H₁₆N₅O₁₄P₃ · xLi⁺
• Numero CAS: 85737-04-8
• Peso molecolare: 523.18 (free acid basis)
• Numero MDL: MFCD00070012
• Codice UNSPSC: 41106305
• ID PubChem: 24895236
• NACRES: NA.77

Proprietà

• Saggio: ~95% (HPLC)
• Livello qualitativo: 200
• Stato: powder
• Colore: white
• Solubilità: H₂O: 100 mg/mL
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: [Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H16N5O14P3.Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1; WDCLDKGIVWUKSE-GWTDSMLYSA-M

Descrizione

Applicazioni

Guanosine 5′-triphosphate lithium salt has been used:

• In ribosome activity assay.
• In tubulin isolation and polymerization.
• In the determination of cell viability.

Azioni biochim/fisiol

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

Guanosine 5′-triphosphate serves as a substrate for guanosine 5′-triphosphate 3′ diphosphate diphosphatase, a hydrolyzing enzyme and guanosine triphosphate guanyltransferase.

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Avvertenza

Stability is much better than sodium salt.

Nota sulla preparazione

Prepared by enzymatic phosphorylation of 5′-GMP.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves