F6020

Fenofibrate

≥99% (TLC), powder, PPARα agonist

• Sinonimo/i: 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
• Formula empirica (notazione di Hill): C₂₀H₂₁ClO₄
• Numero CAS: 49562-28-9
• Peso molecolare: 360.83
• Numero CE: 256-376-3
• Numero MDL: MFCD00133314
• Codice UNSPSC: 12352200
• ID PubChem: 24278015
• NACRES: NA.77

Proprietà

• Nome del prodotto: Fenofibrate, ≥99%, powder
• Livello qualitativo: 100
• Saggio: ≥99%
• Stato: powder
• Colore: off-white
• Ideatore: Abbott
• Temperatura di conservazione: room temp
• Stringa SMILE: CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2
• InChI: 1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3; YMTINGFKWWXKFG-UHFFFAOYSA-N
• Informazioni sul gene: human ... PPARA(5465)

Descrizione

Applicazioni

Fenofibrate has been used:

• to study its effect on plasma lipids, liver phenotype and gene expression
• to study its impact on endothelium-dependent vasodilatation of thoracic aorta
• to administer to NASH knock-in mice along with a high fat diet (HFD) to study its effect

Azioni biochim/fisiol

Fenofibrate increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression. It is used in treating the condition of increased cholesterol levels in the blood, abnormal lipid levels in the body and also hypertriglyceridaemia. Fenofibrate is a lipid regulating drug and proliferator-activated receptor-α (PPARα) mediates its action. It decreases the plasma levels of fibrinogen and C-reactive protein. By this fenofibrate allows better flow-mediated dilatation and reduces the risk of atherosclerosis. Fenofibrate is also known to reduce uric acid levels.

Caratteristiche e vantaggi

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Warning
• Indicazioni di pericolo: H373
• Consigli di prudenza: P260 - P314 - P501
• Classi di pericolo: STOT RE 2 Oral
• Organi bersaglio: Liver
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves