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Key Documents

Altri documenti

C4522

Sigma-Aldrich

Cimetidine

Sinonimo/i:

SKF-92334

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About This Item

Formula empirica (notazione di Hill):
C10H16N6S
Numero CAS:
51481-61-9
Peso molecolare:
252.34
Numero CE:
257-232-2
Numero MDL:
MFCD00133296
Codice UNSPSC:
12352200
ID PubChem:
24277766
NACRES:
NA.77

Forma fisica

powder

Livello qualitativo

200

Ideatore

GlaxoSmithKline

Temperatura di conservazione

2-8°C

Stringa SMILE

CN\C(NC#N)=N\CCSCc1nc[nH]c1C

InChI

1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
AQIXAKUUQRKLND-UHFFFAOYSA-N

Informazioni sul gene

human ... ABCB1(5243) , CYP1A2(1544) , CYP3A4(1576) , HRH2(3274) , SLC9A2(6549) , SLC9A5(6553)
mouse ... Abcb1a(18671) , Abcb1b(18669)
rat ... Slc9a1(24782) , Slc9a3(24784) , Slc9a5(192215)

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Azioni biochim/fisiol

H2 histamine receptor antagonist; I1 imidazoline receptor agonist; anti-ulcer agent. Blocks cancer metastasis by inhibiting the expression of E-selectin on the surface of endothelial cells, thus blocking tumor cell adhesion.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Famotidine

Sigma-Aldrich

F6889

Famotidine

Cimetidine for system suitability European Pharmacopoeia (EP) Reference Standard

Y0001146

Cimetidine for system suitability

JNJ7777120 ≥98% (HPLC)

Sigma-Aldrich

J3770

JNJ7777120

Dexchlorpheniramine maleate European Pharmacopoeia (EP) Reference Standard

D0720800

Dexchlorpheniramine maleate

Acrivastine ≥98% (HPLC)

Sigma-Aldrich

SML0119

Acrivastine

K Kobayashi et al.
Cancer research, 60(14), 3978-3984 (2000-08-05)
Although the beneficial effect of cimetidine on survival in cancer has been clinically demonstrated in colorectal cancer patients, the mode of action of cimetidine has not been elucidated. In this report, we have demonstrated for the first time that cimetidine
Huan Yang et al.
Molecular medicine (Cambridge, Mass.), 28(1), 57-57 (2022-05-17)
Severe COVID-19 is characterized by pro-inflammatory cytokine release syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational and clinical studies suggest famotidine, a histamine 2 receptor (H2R) antagonist widely used to treat gastroesophageal reflux disease, attenuates the clinical
H van der Goot et al.
European journal of medicinal chemistry, 35(1), 5-20 (2000-03-25)
In this review the histaminergic ligands for the histamine H(1), H(2) and H(3) receptors, which are currently used as tools in pharmacological studies, are described. To study interactions with the histamine H(1) receptor, the H(1) agonist 2-aminoethylthiazole has long since
Hiroki Shimizu et al.
ChemMedChem, 17(16), e202200204-e202200204 (2022-06-14)
We synthesized and experimentally tested the passive permeability of more than thirty tetrapeptides mimicking the N-terminus of the pro-apoptotic protein Smac (Second mitochondria-derived activator of caspases). Each peptide bore one or two unnatural Hydrogen Bond Acceptor-bearing Amino Acid (HBA-AA) residues
Y Edrei et al.
British journal of cancer, 107(4), 658-666 (2012-07-19)
The poor prognosis of patients with colorectal-cancer liver metastases (CRLM) and the insufficiency of available treatments have raised the need for alternative curative strategies. We aimed to assess the therapeutic potential of TL-118, a new anti-angiogenic drug combination, for CRLM
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